Eight year outcome after surgery for lumbar disc herniation: a comparison of reoperated and not reoperated patients.
ABSTRACT A retrospective study of 211 patients with unilateral sciatica operated on for lumbar disc herniation during 1988 and 1989 was performed in order to compare the results of reoperated patients with the results of patients operated on only once. The patients completed a standardized questionnaire in 1997 which included questions about reoperations, back and leg pain, functional status and disability pension. Outcome scores were calculated, giving values from 0 (no pain/normal function) to 100 (totally disabled). A follow-up status of 80.1% was obtained; 163 patients answered the questionnaire while six patients had died. 23.9% of the patients (n = 39) had been reoperated on. A recurrent disc herniation at the same level was suspected before the reoperation in 18.4%, but a recurrence was found in only 8.6%. 3.7% were reoperated on more than once. Outcome score was worse among "reoperated" patients (median 45.0, range 0-94) than among patients who only had the primary operation (median 10.5, range 0-81) (P < 0.001). In addition, 34.3% of the "reoperated" patients received a disability pension compared to 9.9% of the patients not reoperated on (P < 0.01). Patients reoperated upon at the same level without peroperative signs of recurrent disc herniation, had an outcome score of 53.0 (range 0-82) compared to a score of 30.0 (range 0-66) in patients with a confirmed recurrence (P < 0.05). The percentage of disability pension was 53.8% versus 9.1%, respectively, for those two groups (P < 0.05). Eight years after operation for lumbar disc herniation, the outcome was significantly worse in "reoperated" patients than in patients operated on once. In addition, reoperated patients with peroperatively confirmed recurrence of the same disc, seemed to have a better outcome than patients without peroperative signs of a recurrence.
- SourceAvailable from: Holm Inger[Show abstract] [Hide abstract]
ABSTRACT: The effectiveness of lumbar fusion for chronic low back pain after surgery for disc herniation has not been evaluated in a randomized controlled trial. The aim of the present study was to compare the effectiveness of lumbar fusion with posterior transpedicular screws and cognitive intervention and exercises. Sixty patients aged 25-60 years with low back pain lasting longer than 1 year after previous surgery for disc herniation were randomly allocated to the two treatment groups. Experienced back surgeons performed transpedicular fusion. Cognitive intervention consisted of a lecture intended to give the patient an understanding that ordinary physical activity would not harm the disc and a recommendation to use the back and bend it. This was reinforced by three daily physical exercise sessions for 3 weeks. The primary outcome measure was the Oswestry Disability Index (ODI). Outcome data were analyzed on an intention-to-treat basis. Ninety-seven percent of the patients, including seven of eight patients who had either not attended treatment (n=5) or changed groups (n=2), completed 1-year follow-up. ODI was significantly improved from 47 to 38 after fusion and from 45 to 32 after cognitive intervention and exercises. The mean difference between treatments after adjustment for gender was -7.3 (95% CI -17.3 to 2.7, p=0.15). The success rate was 50% in the fusion group and 48% in the cognitive intervention/exercise group. For patients with chronic low back pain after previous surgery for disc herniation, lumbar fusion failed to show any benefit over cognitive intervention and exercises.Pain 06/2006; 122(1-2):145-55. DOI:10.1016/j.pain.2006.01.027 · 5.84 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Sciatica in patients with disk disease was long ascribed to pressure put on the sciatic nerve root by a herniated disk. However, a role for chemical factors acting in conjunction with this mechanical insult is suggested by a number of clinical observations: disk surgery does not consistently provide pain relief, large disk herniations are not always symptomatic, severe pain may be present in patients without imaging evidence of nerve root compression, the severity of symptoms and neurological signs is not well correlated with the size of the disk herniation, and conservative therapy is often effective. Experimental studies have provided further evidence for a chemical component: disk herniations can undergo spontaneous resorption, the intervertebral disk is immunogenic, and mediators for inflammation have been identified within intervertebral disk tissue. The current pathophysiological theory incriminates proinflammatory substances secreted by the nucleus pulposus (NP). When preexisting or concomitant mechanical injury to a nerve root occurs, these substances can cause nerve root pain. Animal experiments have established that the NP can induce functional and structural nerve root abnormalities in the absence of mechanical compression and that this effect is mediated by substances located at the surface of NP cells. Methylprednisolone, diclofenac, indomethacin, doxycycline, and cyclosporine induce variable inhibition of this effect. Available information points to tumor necrosis factor-alpha (TNF-alpha) as the main candidate among substances potentially responsible for nerve root pain. Therefore, trials of TNF-alpha antagonists in patients with disk-related sciatica are warranted.Joint Bone Spine 04/2006; 73(2):151-8. DOI:10.1016/j.jbspin.2005.03.003 · 3.22 Impact Factor