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Immune-mediated parasite clearance in mice infected with Plasmodium berghei treatment with manzamine A.

Department of Biological Sciences, National University of Singapore, Singapore.
Parasitology Research (Impact Factor: 2.33). 10/2001; 87(9):715-21. DOI: 10.1007/s004360000366
Source: PubMed

ABSTRACT Manzamine A, a sponge-derived alkaloid, was recently shown to possess in vivo antimalarial activity against the blood stages of the rodent malaria parasite Plasmodium berghei. A single intraperitoneal dose of 100 micromol/kg of manzamine A suppressed parasite growth but was followed by parasite recrudescence. Forty percent of mice with recrudescing parasites were able to recover and clear the fulminating parasitaemia. Examination of sera from these mice revealed that infected mice treated with manzamine A had a suppressed IFN-gamma production but an increase in their IL-10 and IgG production. The prolonged survival of infected mice treated with manzamine A and the eventual clearance of recrudescing parasites in some of these mice involve a down-regulation of Thl responses and a switch to antibody dependent-Th2 responses.

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    • "The biological activities of new metabolites from sponges have been reported in hundreds of scientific papers. Sponges have the potential to provide future drugs against important diseases such as cancer (Bai et al. 1993; Blackburn et al. 1999; Hood et al. 2002; Molinski et al. 2009), inflammation (Tan et al. 1997; Pope et al. 1999; Festaa et al. 2012), cardiovascular (Maryanoff et al. 1993; Shuman et al. 1993; Chackalamannil 2001), viral (Müller et al. 1987; Ford et al. 1999; Wellington et al. 2000), plasmodial (Ang et al. 2001) and bacterial (D_Ambrosio et al. 1996). Previous work on another species of the genus Dragmacidon collected from Andaman Sea in Thailand resulted in the isolation of a number of b-carboline alkaloids; some of them are characterised by possessing potent anti-inflammatory and antitumour activities (Pedpradab et al. 2004). "
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    • "Youssaf et al., 2002). This antimalarial effect of manzamine-A is due to an enhanced immune response (Ang et al., 2001). "
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