A Prospective Study of Drinking Patterns in Relation to Risk of Type 2 Diabetes Among Men

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Diabetes (Impact Factor: 8.1). 10/2001; 50(10):2390-5. DOI: 10.2337/diabetes.50.10.2390
Source: PubMed


Using data from a 12-year prospective study, we determined the importance of the pattern of alcohol consumption as a risk factor for type 2 diabetes in a cohort of 46,892 U.S. male health professionals who completed biennial postal questionnaires. Overall, 1,571 new cases of type 2 diabetes were documented. Compared with zero alcohol consumption, consumption of 15-29 g/day of alcohol was associated with a 36% lower risk of diabetes (RR = 0.64; 95% CI 0.53-0.77). This inverse association between moderate consumption and diabetes remained if light drinkers rather than abstainers were used as the reference group (RR = 0.60, CI 0.50-0.73). There were few heavy drinkers, but the inverse association persisted to those drinking >/=50 g/day of alcohol (RR = 0.60, CI 0.43-0.84). Frequency of consumption was inversely associated with diabetes. Consumption of alcohol on at least 5 days/week provided the greatest protection, even when less than one drink per drinking day was consumed (RR = 0.48, CI 0.27-0.86). Compared with infrequent drinkers, for each additional day per week that alcohol was consumed, risk was reduced by 7% (95% CI 3-10%) after controlling for average daily consumption. There were similar and independent inverse associations for beer, liquor, and white wine. Our findings suggested that frequent alcohol consumption conveys the greatest protection against type 2 diabetes, even if the level of consumption per drinking day is low. Beverage choice did not alter risk.

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Available from: Carlos A Camargo, Sep 03, 2015
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    • "Alcohol is unique among substance abuse drugs, as it is a natural by-product of fermentation. Moderate drinking of alcohol may offer health benefits (Marugame et al. 2007), including reduction in cardiovascular disease (Baer et al. 2002), ischemic strokes (Zeng et al. 2012; Peng et al. 2013), stress levels, incidence of type II diabetes (Conigrave et al. 2001; Koppes et al. 2005) and gallstone disease (Leitzmann et al. 1999). Excessive alcohol consumption, however, is a common cause of preventable death in most countries, and imposes a major socioeconomic burden. "
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    ABSTRACT: Alcohol abuse and alcoholism incur a heavy socioeconomic cost in many countries. Both genetic and environmental factors contribute to variation in the inebriating effects of alcohol and alcohol addiction among individuals within and across populations. From a genetics perspective, alcohol sensitivity is a quantitative trait determined by the cumulative effects of multiple segregating genes and their interactions with the environment. This review summarizes insights from model organisms as well as human populations that represent our current understanding of the genetic and genomic underpinnings that govern alcohol metabolism and the sedative and addictive effects of alcohol on the nervous system. Electronic supplementary material The online version of this article (doi:10.1007/s00438-013-0808-y) contains supplementary material, which is available to authorized users.
    MGG Molecular & General Genetics 01/2014; 289(3). DOI:10.1007/s00438-013-0808-y · 2.73 Impact Factor
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    • "While several studies showed a U-shaped relationship between alcohol and diabetes risk [1], others reported increased risks of type 2 diabetes in alcohol consumption categories of ≥25 g/day [2], >40 g/day [3], and >3 drinks per day [4]. Another study found a progressive decrease in the risk of type 2 diabetes up to a consumption of ≥50 g of alcohol per day [5]. The inconsistent results may be ascribed to differences in ascertainment of alcohol consumption and diabetes mellitus among studies and different genetic susceptibilities to alcohol exposure among study populations. "
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    ABSTRACT: This study investigated the association of ADH1B (rs1229984) and ALDH2 (rs671) polymorphisms with glucose tolerance status, as determined by a 75-g oral glucose tolerance test, and effect modification of these polymorphisms on the association between alcohol consumption and glucose intolerance in male officials of the Self-Defense Forces. The study subjects included 1520 men with normal glucose tolerance, 553 with prediabetic condition (impaired fasting glucose and impaired glucose tolerance), and 235 men with type 2 diabetes. There was an evident interaction between alcohol consumption and ADH1B polymorphism in relation to type 2 diabetes (interaction P=.03). The ALDH24∗87Lys allele was associated with a decreased prevalence odds of type 2 diabetes regardless of alcohol consumption. In conclusion, the ADH1B polymorphism modified the association between alcohol consumption and type 2 diabetes. A positive association between alcohol consumption and type 2 diabetes was confounded by ALDH2 polymorphism.
    01/2011; 2011(2090-2972). DOI:10.1155/2011/583682
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    • "Although the majority subjects in this group were light and non-liquor drinkers, we could not rule out the possibility that some of them consumed excessive alcohol over a short period of time. Interestingly, inconsistent with previous reports [23], the increased risk was also observed in regular light drinkers (5-7 d/wk, 0.1-19.9 g/d). "
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    ABSTRACT: The U-shaped relationship between alcohol consumption and diabetes mellitus was observed among western populations. However, few studies have systematically evaluated the association in Chinese. We aimed to investigate the associations of alcohol consumption with diabetes mellitus and impaired fasting glycemia (IFG) among middle-aged and elderly Chinese. We examined 1,458 men and 1,831 women aged 50 to 70 from Beijing and Shanghai China in a cross-sectional survey. Fasting glucose, adipokines and markers of inflammation were measured. Macronutrients and alcohol consumption were assessed with standardized questionnaires. Compared with abstainers, alcohol consumption was associated with a decreased risk of having diabetes mellitus in women (OR: 0.41, 95%CI: 0.22-0.78) after controlling for socio-demographic factors, physical activity, smoking, family income, family history of cardiovascular disease or diabetes, macronutrients intake, body mass index, and markers of inflammation and adipokines. In men, both low and high alcohol consumptions were associated with increased risks of having combined diabetes and IFG (ORs 1.36 [95%CI: 1.02-1.82] and 1.50 [95%CI: 1.04-2.15], respectively]. In the multivariable stratified analyses among men, moderate drinkers who had drinking days of ≥ 5 days/week had a deceased likelihood (OR: 0.61, 95%CI: 0.37-0.98) and liquor drinkers had an increased likelihood (OR: 1.47, 95%CI: 1.09-1.98) of having combined diabetes and IFG respectively, compared with the abstainers. An approximately J-shaped association was observed between alcohol consumption and combined diabetes and IFG among men compared with abstainers in Chinese. Whether moderate alcohol intake could help decrease diabetic risk among Chinese people warrants further investigation.
    BMC Public Health 11/2010; 10(1):713. DOI:10.1186/1471-2458-10-713 · 2.26 Impact Factor
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