Article

A rare association between acromegaly and pheochromocytoma.

Department of Surgery, Division of General Surgery, University of Alberta, Cross Cancer Institute, Edmonton, Alberta, Canada.
The American Journal of Surgery (Impact Factor: 2.52). 09/2001; 182(2):185-7. DOI: 10.1016/S0002-9610(01)00678-X
Source: PubMed

ABSTRACT The occurrence of multiple endocrine tumors is rare; however, they may be found with hereditary diseases such as multiple endocrine neoplasia (MEN). The endocrine tumors involved with these diseases are well documented. We present a case of a patient with a pheochromocytoma and a growth hormone (GH) secreting pituitary adenoma. This association is not described with any of the known MEN syndromes. The association may be a cross-over MEN syndrome or a secondarily induced GH-secreting pituitary adenoma from a pheochromocytoma producing growth hormone releasing hormone (GHRH) instead of catecholamines.

0 Bookmarks
 · 
53 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: A 59-year old man, who had a hypertensive crisis during transsphenoidal surgery for a pituitary macroadenoma, was subsequently found to have an adrenal pheochromocytoma. A total of twenty-five cases describing the coexistence of a pituitary adenoma and pheochromocytoma have been reported in the literature over the past 40 years. Among pituitary tumors, acromegaly has been the most common. In an effort to identify the relationship between the two tumors, multiple theories have been suggested including fortuitous association, overlap or variants of MEN syndromes, and ectopic production of a trophic hormone by the pheochromocytoma. The high risk of mortality and morbidity associated with undiagnosed pheochromocytoma warrants careful attention to the possibility of such a coexistence.
    Pituitary 02/2003; 6(4):221-5. · 2.67 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Acromegaly is characterized by sustained elevation of circulating growth hormone (GH) and insulin-like growth factor I (IGF-I), and is clearly associated with increased morbidity and overall mortality mainly due to cardiovascular, metabolic, and respiratory diseases. Although cancer-related mortality varies widely amongst retroperspective studies, it appears to be consistently elevated mainly in patients with uncontrolled disease. We review individual tumor types including neoplasms of the colon, breast, prostate, and thyroid where in vitro, animal studies, and studies in non-acromegalic cancer patients have established a role for the GH/IGF-I axis in tumor progression and possibly initiation. We highlight deficiencies in data in acromegalic patients where the evidence is less convincing. Instead, we explore the hypothesis that acromegaly, independent of hormone secretion, is a disease that heralds genetic and/or epigenetic alterations predisposing to cancer risk elsewhere.
    Reviews in Endocrine and Metabolic Disorders 04/2008; 9(1):41-58. · 4.58 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: We present the case of a 56-year-old woman who, 5 years after receiving a diagnosis of unilateral adrenal pheochromocytoma and primary hyperparathyroidism, was diagnosed with acromegaly caused by a growth hormonesecreting pituitary adenoma. No germ-line mutations in RET, VHL and MEN-1 gene were detected. Medullar thyroid carcinoma was also ruled out. Therefore, the present case shows coexistence of a tumor characteristic of MEN 2 syndrome (pheochromocytoma) with a growth hormone-secreting pituitary tumor characteristic of MEN 1 syndrome and primary hyperparathyroidism, which can be observed in both multiple endocrine neoplasia syndromes, but without germline mutations in RET, VHL and MEN-1.
    Endocrinología y Nutrición. 06/2006; 53(6).