Coffee and Alcohol Intake and Risk of Ovarian Cancer: An Italian Case-Control Study

Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy.
Nutrition and Cancer (Impact Factor: 2.32). 01/2001; 39(1):29-34. DOI: 10.1207/S15327914nc391_4
Source: PubMed


The relation between coffee and alcohol intake and ovarian cancer risk was analyzed in a case-control study conducted in Italy between 1992 and 1999. Cases were 1,031 women, aged 18-79 years, with incident, histologically confirmed invasive epithelial ovarian cancer, and controls were 2,411 women, aged 17-79 years, admitted to the hospital for acute nonneoplastic non-hormone-related diseases. Coffee intake (mostly espresso and mocha) was not associated with ovarian cancer risk, with an odds ratio (OR) of 0.93 [95% confidence interval (CI) = 0.69-1.27] in drinkers of > or = 4 cups/day compared with drinkers of < 1 cup/day. No meaningful relation was observed with cappuccino (OR = 1.06, 95% CI = 0.85-1.32 for drinkers compared with nondrinkers), decaffeinated coffee (OR = 0.64, 95% CI 0.42-0.96), and tea intake (OR = 0.90, 95% CI = 0.75-1.08). Total alcohol intake was not associated with ovarian cancer risk (OR = 1.09, 95% CI = 0.76-1.57 in drinkers of > or = 36 g/day compared with never drinkers). No relationship was found with wine (OR = 1.03, 95% CI = 0.70-1.50 for > 39 g/day compared with never drinkers), beer, amari, grappa, and spirits. No significant heterogeneity was found for coffee or total alcohol intake across strata of age, education, parity, oral contraceptive use, family history of ovarian/breast cancer, body mass index, and calorie intake. This study, based on a large data set; provides no support for a causal association between invasive epithelial ovarian cancer risk and coffee and alcohol intake.

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Available from: Maurizio Montella, Oct 13, 2015
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    • "Three epidemiologic studies were excluded because there was no direct assessment of tea intake [41], there was no assessment of the relationship between tea intake and EOC [42] or no confidence intervals were provided [43]. Other epidemiologic studies were excluded because green tea intake was not specifically measured [47] [48] [49] [50] [51] [52] [53] [54] [55] [56] [57] [58] [59]. One study was reported twice [18] [19], and one study was first reported in an abstract form [16] and then as a peer-reviewed article [17]. "
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    ABSTRACT: This systematic review was conducted to examine the effects of green tea or green tea components on the prevention and progression of epithelial ovarian cancer. Using Medline, EMBASE and SciVerse (last researched: July 2011), we retrieved 22 articles including 5 epidemiological studies. In epithelial ovarian cancer cell lines, green tea and green tea components have been shown to downregulate the expression of proteins involved in inflammation, cell signalization, cell motility and angiogenesis. Green tea and green tea components would induce apoptosis and could potentiate the effects of cisplatin, a chemotherapeutic agent. In human observational studies, significant associations between green tea intake and both decreased ovarian cancer occurrence and better prognosis were reported. Available literature suggests potential molecular targets for green tea in ovarian cancer treatment and also provides data supporting the clinical evaluation of the role of green tea or green tea components in ovarian cancer prevention and treatment.
    Gynecologic Oncology 05/2012; 126(3):491-8. DOI:10.1016/j.ygyno.2012.04.048 · 3.77 Impact Factor
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    • "Coffee drinking and ovarian cancer risk was investigated in 16 case-control studies (Trichopoulos et al, 1981; Hartge et al, 1982; Byers et al, 1983; Cramer et al, 1984; La Vecchia et al, 1984; Tzonou et al, 1984; Miller et al, 1987; Whittemore et al, 1988; Polychronopoulou et al, 1993; Kuper et al, 2000; Tavani et al, 2001; Jordan et al, 2004; Riman et al, 2004; Baker et al, 2007) and, including this study, five cohort studies (Snowdon and Phillips, 1984; Stensvold and Jacobsen, 1994; Larsson and Wolk, 2005a; Silvera et al, 2007). We had to exclude from the meta-analysis studies that did not report 95% CIs (Trichopoulos et al, 1981; Byers et al, 1983; Cramer et al, 1984; Tzonou et al, 1984; Stensvold and Jacobsen, 1994). "
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    ABSTRACT: In a cohort study, ovarian cancer (280 cases) showed no significant association with tea or coffee, the multivariable rate ratios being 0.94 (95% confidence interval (CI): 0.89, 1.00) and 1.04 (95% CI: 0.97, 1.12) per cup per day, respectively. A meta-analysis also produced no significant findings overall, though the cohort studies showed a significant inverse association for tea.
    British Journal of Cancer 12/2007; 97(9):1291-4. DOI:10.1038/sj.bjc.6604008 · 4.84 Impact Factor
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    • "In contrast, two case–control studies [14, 24] and one cohort study (among women with high dietary folate intake) [17] found an inverse association between wine consumption and ovarian cancer risk. However, there was no association with wine (or total alcohol) consumption in other studies [13, 18, 19]. "
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    ABSTRACT: Whether alcohol consumption influences ovarian cancer risk is unclear. Therefore, we investigated the association between alcohol intake at various ages and risk of ovarian cancer. Among 90,371 eligible members of the California Teachers Study cohort who completed a baseline alcohol assessment in 1995-1996, 253 women were diagnosed with epithelial ovarian cancer by the end of 2003. Multivariate Cox proportional hazards regression analysis was performed to estimate relative risks (RRs) and 95% confidence intervals (CIs). Consumption of total alcohol, beer, or liquor in the year prior to baseline, at ages 30-35 years, or at ages 18-22 years was not associated with risk of ovarian cancer. Consumption of at least one glass per day of wine, compared to no wine, in the year before baseline was associated with increased risk of developing ovarian cancer: RR = 1.57 (95% CI 1.11-2.22), P (trend) = 0.01. The association with wine intake at baseline was particularly strong among peri-/post-menopausal women who used estrogen-only hormone therapy and women of high socioeconomic status. Alcohol intake does not appear to affect ovarian cancer risk. Constituents of wine other than alcohol or, more likely, unmeasured determinants of wine drinking were associated with increased risk of ovarian cancer.
    Cancer Causes and Control 03/2007; 18(1):91-103. DOI:10.1007/s10552-006-0083-x · 2.74 Impact Factor
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