Hodson L, Skeaff CM, Chisholm WL.. The effect of replacing dietary saturated fat with polyunsaturated or monounsaturated fat on plasma lipids in free-living young adults. Eu J Clin Nutr 55, 908-915

Department of Human Nutrition, University of Otago, Dunedin, New Zealand.
European Journal of Clinical Nutrition (Impact Factor: 2.95). 11/2001; 55(10):908-15. DOI: 10.1038/sj.ejcn.1601234
Source: PubMed

ABSTRACT To examine, in free-living adults eating self-selected diets, the effects on plasma cholesterol of substituting saturated fat rich foods with either n-6 polyunsaturated or monounsaturated fat rich foods while at the same time adhering to a total fat intake of 30-33% of dietary energy.
Two randomised crossover trials.
General community.
Volunteer sample of healthy free-living nutrition students at the University of Otago. Trial I, n=29; and trial II, n=42.
In trials I and II participants were asked to follow for 2(1/2) weeks a diet high in saturated fat yet with a total fat content that conformed to nutrition recommendations (30-33% energy). During the 2(1/2) week comparison diet, saturated fat rich foods were replaced with foods rich in n-6 polyunsaturated fats (trial I) whereas in trial II the replacement foods were rich in monounsaturated fats. Participants were asked to maintain a total fat intake of 30-33% of energy on all diets.
Energy and nutrient intakes, plasma triglyceride fatty acids, and plasma cholesterol.
When replacing saturated fat with either n-6 polyunsaturated fat or monounsaturated fat, total fat intakes decreased by 2.9% energy and 5.1% energy, respectively. Replacing saturated fat with n-6 polyunsaturated fat (trial I) lowered plasma total cholesterol by 19% [from 4.87 (0.88) to 3.94 (0.92) mmol/l, mean (s.d.)], low density lipoprotein cholesterol by 22% [from 2.87 (0.75) to 2.24 (0.67) mmol/l], and high density lipoprotein cholesterol by 14% [from 1.39 (0.36) to 1.19 (0.34) mmol/l], whereas replacing saturated fat with monounsaturated fat (trial II) decreased total cholesterol by 12%, low density lipoprotein cholesterol by 15%, and high density lipoprotein cholesterol by 4%, respectively. The change in the ratio of total to high density lipoprotein cholesterol was similar during trial I and trial II.
Young adults are very responsive to dietary-induced changes in plasma cholesterol even when an isocaloric replacement of saturated fat with n-6 polyunsaturated or monounsaturated fat is not achieved. Replacing saturated fat with either n-6 polyunsaturated or monounsaturated fat is equally efficacious at reducing the total to high density lipoprotein cholesterol ratio.
University of Otago, Meadow Lea Ltd.

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    • "Unsaturated fatty acids are widely considered to have a more beneficial biological effect in humans, with many arguing in favour of replacing saturated fats with unsaturated fats, rather than carbohydrates , to cause a favourable change in serum lipid profiles (Hodson et al., 2001). However, there is still debate over whether monounsaturated (MUFAs) or polyunsaturated (PUFAs) fats are a more beneficial option. "
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