A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK).

Center for Supramolecular Science and Department of Chemistry, University of Miami, PO Box 249118, Coral Gables, Florida 33124, USA.
Organic Letters (Impact Factor: 6.32). 11/2001; 3(21):3277-80. DOI: 10.1021/ol0101638
Source: PubMed

ABSTRACT [structure: see text]. A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.