Article

Effect of the growth medium on the in vitro antifungal activity of micafungin (FK-463) against clinical isolates of Candida dubliniensis.

Department of Paediatrics, University of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany.
Journal of Antimicrobial Chemotherapy (impact factor: 5.07). 12/2001; 48(5):713-5. pp.713-5
Source: PubMed

ABSTRACT Micafungin (FK-463), a member of the new candin family of antifungal agents, was highly active against clinical isolates of Candida albicans and Candida dubliniensis. The in vitro activity of micafungin suggested that it was more potent than fluconazole, flucytosine, amphotericin B or voriconazole against C. albicans, and comparable or moderately less effective against C. dubliniensis isolates when high-resolution medium (HR) was used. Lower MICs of micafungin were recorded when RPMI 2% or AM3 2% media were used, indicating an influence of the growth medium on the MIC.

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Keywords

amphotericin B
 
C. albicans
 
C. dubliniensis
 
Candida albicans
 
Candida dubliniensis
 
clinical
 
comparable
 
fluconazole
 
high-resolution medium
 
Lower MICs
 
micafungin
 
new candin family
 
vitro activity