Article

Antiviral pathway activation in patients with chronic fatigue syndrome and acute infection.

Department of Neurology, University of Glasgow, Scotland, United Kingdom.
Clinical Infectious Diseases (impact factor: 9.15). 01/2002; 33(12):2080-1. DOI:10.1086/324357 pp.2080-1
Source: PubMed

ABSTRACT Gene expression of key enzymes in 2 antiviral pathways (ribonuclease latent [RNase L] and RNA-regulated protein kinase [PKR]) was compared in 22 patients with chronic fatigue syndrome (CFS), 10 patients with acute gastroenteritis, and 21 healthy volunteers. Pathway activation in the group of patients with infections differed significantly from that of the other 2 groups, in whom there was no evidence of upregulation. Therefore, assay of activation is unlikely to provide the basis for a diagnostic test for CFS.

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Keywords

10 patients
 
2 antiviral pathways
 
2 groups
 
21 healthy volunteers
 
22 patients
 
activation
 
diagnostic test
 
Gene expression
 
key enzymes
 
Pathway activation
 
patients
 
RNA-regulated protein kinase [PKR]
 
upregulation