[Development of new antidiabetic drugs through the advanced knowledge of molecular biology in insulin signal transduction].
First Department of Internal Medicine, Toyama Medical & Pharmaceutical University.Nippon rinsho. Japanese journal of clinical medicine 12/2001; 59(11):2179-85.
The advancement of molecular biology in the field of insulin signal transduction is remarkable and the knowledge acquired through the recent research can be applied to the development of new antidiabetic drugs. There are several serine-threonine kinases and tyrosine phosphatases which can decrease insulin action at the state of diabetes and adipocytokines, which are produced from enlarged adipocytes, may affect insulin signal transduction. To prevent these proteins and cytokines from suppressing insulin action, specific molecular targets could be identified and the new agents can be developed for the normal insulin signaling and the development of new antidiabetic drugs is ongoing at present time.
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