Article

Molecular pathogenesis of pancreatic ductal adenocarcinoma and clinical implications

University of Liverpool, Department of Surgery, 5th Floor UCD Building, Royal Liverpool University Hospital, Daulby Street, Liverpool L69 3GA, UK.
Surgical Oncology (Impact Factor: 2.37). 07/2001; 10(1-2):1-23. DOI: 10.1016/S0960-7404(01)00016-0
Source: PubMed

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a significant cause of cancer death worldwide. PDAC is also one of the best-studied cancers with regard to molecular pathogenesis. The chief risk factors associated with PDAC are smoking and pancreatitis, in addition genetic predisposition seems to play a major role. This genetic predisposition may in some cases be indirect, for example via the elevated risk of pancreatitis seen in patients with hereditary pancreatitis (HP). The elucidation of the molecular causes of PDAC has enabled the provision of secondary screening for PDAC in conditions such as HP. This review is concerned with the molecular pathogenesis of PDAC and the application of this basic scientific understanding into state-of-the-art clinical practice.

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    • "Pancreas cancer is a most aggressive malignancy with dismal outcome for patients. The disease is usually advanced at presentation (Haycox et al. 1998a) and the aggressive biological phenotype is exceptionally resistant to all forms of therapy (Magee et al. 2001). Surgery offers the only possibility of cure, but even in those curatively resected, the median survival is short (13–18 months) and 5-year survival at best 15–26% (Mosca et al. 1997; Kuhlman et al. 2004; Yeo et al. 1995). "
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