The role of Fas ligand in immune privilege
La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA. Nature Reviews Molecular Cell Biology
(Impact Factor: 37.81).
01/2002; 2(12):917-24. DOI: 10.1038/35103104
Immune privilege is a property of some sites in the body, whereby immune responses are limited or prevented. One explanation that has been proposed for this phenomenon is engagement of the pro-apoptotic molecule Fas by its ligand (FasL), which leads to apoptosis, and consequently limits an inflammatory response. This idea has recently been challenged, and here we review the evidence for and against a role for FasL in immune privilege.
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