Bohm F, Edge R, Burke M & Truscott TG: Dietary uptake of lycopene protects human cells from singlet oxygen and nitrogen dioxide - ROS components from cigarette smoke. J. Photochem. Photobiol. B 64, 176-178

Meclinic Berlin, Friedrichstrasse 71, 10117 Berlin, Germany.
Journal of Photochemistry and Photobiology B Biology (Impact Factor: 2.96). 12/2001; 64(2-3):176-8. DOI: 10.1016/S1011-1344(01)00221-4
Source: PubMed


There is current interest in the health benefits of dietary carotenoids and the possible deleterious effects on certain sub-populations such as smokers. Here we report in vivo protection of human lymphocytes, conferred by dietary supplementation of lycopene rich foods against the reactive oxygen species, NO(2)(*) radical (by electron transfer) and 1(O)(2) (by energy transfer). It was found that a lycopene rich diet, maintained for 14 days, increased the serum lycopene level 10 fold compared to serum obtained after the same period, where a typical western European diet had been consumed. Relative lymphocyte protection factors of 17.6 and 6.3 against NO(2)(*) radical and 1(O)(2), respectively, were obtained, which re-enforce epidemiological data, showing protection against several chronic diseases by tomato lycopene.

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    • "Last et al. (1994) [53] Kienast et al. (1994) [54] Vitamin E Guth and Mavis (1986) [55] Sevanian et al. (1982) [56] Depletion of antioxidants Kelly and Tetley (1997) [57] Kelly et al. (1996) [58] Vitamin C Rietjens et al. (1986) [59] Mohsenin (1987) [60] Lipid peroxidation Sevanian et al. (1982) [56] Khopde et al. (1998) [61] Lycopene Böhm et al. (2001) [62] Particulate matter (PM) "
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    Oxidative medicine and cellular longevity 07/2014; 2014(1-2):671539. DOI:10.1155/2014/671539 · 3.36 Impact Factor
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    • "D g ) , which have been shown to be capable of inducing DNA damage and to be mutagenic ( Di Mascio et al . , 1990 ; Barros et al . , 2001 ; Bohm et al . , 2001 ; Murthy et al . , 2005 ; Sthal et al . , 2006"
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    • "The human body is unable to synthesize carotenoids, which qualifies diet as the only source of these components in blood and tissues. At least 85% of our dietary lycopene comes from tomato fruit and tomato-based products (Bohm and others 2001). "
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    ABSTRACT:   Lycopene is the principal pigment of the carotenoids naturally found in tomatoes and is important not only because of the color it imparts but also because of the recognized health benefits associated with its presence. Red tomatoes typically contain about 95% of their lycopene as the all-trans isomer, the most stable form. In tangerine tomatoes, on the other hand, the lycopene is present as tetra-cis-lycopene, a geometric isomer of all-trans lycopene. Lycopene is a major component found in blood serum. This carotenoid has been extensively studied for its antioxidant and cancer-preventing properties. Prevention of heart disease has been shown to be another antioxidant role played by lycopene because it reduces the accumulation of platelets that eventually lead to blood clots, heart attacks, and strokes. In contrast to many other food phytonutrients whose effects have only been studied in animals, lycopene from tomatoes has been repeatedly studied in humans and found to be protective against several cancers, which now include colorectal, prostate, breast, lung, and pancreatic cancers. This review outlines the background information dealing with lycopene and presents the most comprehensive and current understanding of its potential functional role in human health.
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