Prevalence of restless legs syndrome among men aged 18–64 years: an association with somatic disease and neuropsychiatric symptoms

Department of Medical Sciences/Occupational and Environmental Medicine, University Hospital, Uppsala, Sweden.
Movement Disorders (Impact Factor: 5.68). 12/2001; 16(6):1159-63.
Source: PubMed


Standardized diagnostic criteria determined by the International Restless Legs Syndrome Study Group were used to investigate the current prevalence of restless legs syndrome (RLS). Possible associations between RLS and neuropsychiatric and somatic complaints were also investigated. A random sample of 4,000 men living in central Sweden were sent a questionnaire that included questions about sleep habits, symptoms of sleepiness, and somatic and neuropsychiatric complaints. Four symptom questions accepted as minimal diagnostic criteria for RLS were also included. Odds (OR) ratios and 95% confidence interval (CI) for different variables were calculated by means of multivariate logistic regression; 5.8% of the men suffered from RLS. The prevalence of RLS increased with age. Sleep-related complaints were more frequent among the RLS sufferers. Complaints of headache at awakening and daytime headache were reported three to five times more frequently among RLS sufferers and there was a tendency toward reported social isolation related to RLS. Subjects with RLS more frequently reported depressed mood (OR, 2.6; 95% CI, 1.8-3.8), and complained more often of reduced libido (OR, 2.2; 95% CI, 1.4-3.3). RLS sufferers more frequently reported hypertension (OR, 1.5; 95% CI, 0.9-2.4) and heart problems (OR, 2.5; 95% CI, 1.4-4.3). Results show that restless legs syndrome is common among men. It is hypothesized that RLS may be associated with several somatic and neuropsychiatric symptoms.

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    • "The association between RLS and PLMS and the risk of hypertension, however, is controversial Ohayon and Roth,( 2002); Ulfberg et al. (2001);Winkelman et al. (2008). Sforza et al. (1999) and Siddiqui et al. (2007), have reported that episodes of PLM are associated with significant repetitive sleep time elevations of heart rate plus systolic blood pressure (SBP) and diastolic blood pressure (DBP). "

    01/2015; 04(02). DOI:10.4172/2167-1168.1000235
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    • "Changes in sleep quantity and/or quality due to RLS has been suggested as being potentially associated with prevalent hypertension [65]. Among 4000 men aged 18e64 y in whom RLS was self-reported in questionnaires; Ulfberg et al. found that after adjustments for age, witnessed apnea, smoking, and alcohol consumption , RLS sufferers were more likely to report hypertension [66]. In a study by Ohayon et al. [67] including 18 980 individuals from five European countries, 732 met criteria for RLS and presented with a two-fold higher risk for elevated BP (21.8 vs. 11.1% for patients with and without RLS, respectively, for the association between hypertension and RLS after adjustment for confounders). "
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    ABSTRACT: Cardiovascular autonomic control changes across sleep stages. Thus, blood pressure (BP), heart rate and peripheral vascular resistances progressively decrease in non rapid eye movement sleep. Any deterioration in sleep quality or quantity may be associated with an increase in nocturnal BP which could participate in the development or poor control of hypertension. In the present report, sleep problems/disorders, which impact either the sleep quality or quantity, are reviewed for their interaction with BP regulation and their potential association with prevalent or incident hypertension. Obstructive sleep apnea syndrome, sleep duration/deprivation, insomnia, restless legs syndrome and narcolepsy are successively reviewed. Obstructive sleep apnea is clearly associated with the development of hypertension that is only slightly reduced by continuous positive airway pressure treatment. Shorter and longer sleep durations are associated with prevalent or incident hypertension but age, gender, environmental exposures and ethnic disparities are clear confounders. Insomnia with objective short sleep duration, restless legs syndrome and narcolepsy may impact BP control, needing additional studies to establish their impact in the development of permanent hypertension. Addressing sleep disorders or sleep habits seems a relevant issue when considering the risk of developing hypertension or the control of pre-existent hypertension. Combined sleep problems may have potential synergistic deleterious effects.
    Sleep Medicine Reviews 12/2014; 18(6). DOI:10.1016/j.smrv.2014.03.003 · 8.51 Impact Factor
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    • "There have been 20 previous cross-sectional epidemiologic studies that have looked at the relationship between RLS and hypertension, heart disease, and stroke. Of these 20 studies, 15 suggested an increased risk of hypertension, CVD, CAD, cerebrovascular disease, or heart disease in patients with RLS/PLMS [2, 10, 14, 16, 40, 61, 71, 78, 84, 87, 97, 121, 132, 136, 137]. Five cross-sectional epidemiologic studies reported no associated or a reduced risk of hypertension and CVD compared to patients without RLS [30, 55, 101, 141, 142]. "
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    ABSTRACT: Untreated sleep disorders may contribute to secondary causes of uncontrolled hypertension, cardiovascular disease (CVD), and stroke. Restless legs syndrome, or Willis-Ekbom Disease (RLS/WED), is a common sensorimotor disorder with a circadian rhythmicity defined by an uncontrollable urge to move the legs that worsens during periods of inactivity or at rest in the evening, often resulting in sleep disruptions. Sleep disorders such as insomnia and obstructive sleep apnea (OSA) are established risk factors for increased risk of hypertension and vascular diseases. This literature review outlines the lessons learned from studies demonstrating insomnia and OSA as risk factors for hypertension and vascular diseases to support the epidemiologic and physiologic evidence suggesting a similar increase in hypertension and vascular disease risk due to RLS. Understanding the relationships between RLS and hypertension, CVD, and stroke has important implications for reducing the risks associated with these diseases.
    Journal of Neurology 08/2013; 261(6). DOI:10.1007/s00415-013-7065-1 · 3.38 Impact Factor
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