Molecular imprinting within hydrogels. Adv Drug Deliv Rev

NSF Program on Therapeutic and Diagnostic Devices, Purdue University, West Lafayette, IN 47907, USA.
Advanced Drug Delivery Reviews (Impact Factor: 15.04). 02/2002; 54(1):149-61. DOI: 10.1016/S0169-409X(01)00246-0
Source: PubMed

ABSTRACT Hydrogels have been used primarily in the pharmaceutical field as carriers for delivery of various drugs, peptides and proteins. These systems have included stimuli-responsive gels that exhibit reversible swelling behavior and hence can show modulated release in response to external stimuli such as pH, temperature, ionic strength, electric field, or specific analyte concentration gradients. The focus of this article is to review molecular imprinting within hydrogels and discuss recent efforts on analyte-responsive intelligent gels, specifically suggesting the possibility of utilizing molecular imprinting strategies to impart analyte specificity and responsiveness within these systems. Molecular imprinting is an emerging field that produces precise chemical architecture that can bind analytes and differentiate between similar molecules with enantiomeric resolution. On the forefront of imprinting gel systems are intelligent, stimuli-sensitive imprinted gels that modify their swelling behavior and in turn modulate their analyte binding abilities. We discuss the challenges creating an imprinting effect in hydrogels and the possibilities of using molecularly imprinted mechanisms within controlled release gels.

34 Reads
    • "Besides the concept shown in Figure 3, the concept of intelligent drug delivery which refers to the predictable release of a drug in response to specific stimuli, such as the presence of another molecule has been a well-established drug release way from MIP carrier. Some excellent reviews have been published on the investigation of various aspects of MIPs in drug delivery (Byrne et al., 2002; Hillberg et al., 2005; Kryscio & Peppas, 2009; Rangasamy & Parthiban, 2010; Wang & Von Recum, 2011; Lulinski, 2013). Apart from numerous research reports published on various concepts of MIP-based DDS, some important contributions in the form of book chapters have also been devoted on extensive introduction and applications of MIP-based intelligent drug delivery (Alvarez-Lorenzo & Concheiro, 2013a,b; Alvarez-Lorenzo et al., 2013c–d). "
    [Show abstract] [Hide abstract]
    ABSTRACT: This review is aimed to discuss the molecular imprinted polymer (MIP)-based drug delivery systems (DDS). Molecular imprinted polymers have proved to possess the potential and also as a suitable material in several areas over a long period of time. However, only recently it has been employed for pharmaceuticals and biomedical applications, particularly as drug delivery vehicles due to properties including selective recognition generated from imprinting the desired analyte, favorable in harsh experimental conditions, and feedback-controlled recognitive drug release. Hence, this review will discuss their synthesis, the reason they are selected as drug delivery vehicles and for their applications in several drug administration routes (i.e. transdermal, ocular and gastrointestinal or stimuli-reactive routes).
    Drug Delivery 09/2014; DOI:10.3109/10717544.2014.970297 · 2.56 Impact Factor
  • Source
    • "Below the LCST, these hydrogels are swollen in water. As the temperature is increased above LCST, it undergoes abrupt changes in volume and shrinks quickly [13] [14]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: The acrylamide-sodium acrylate hydrogel was synthesized by free radical polymerization of the method of solution polymerization. Dynamic swelling tests were conducted at 25, 40, and 60°C temperatures, in order to investigate the swelling properties of the synthesized hydrogel. The results have shown that swelling content and swelling rate of the hydrogel increase with increasing the swelling water temperature. The diffusivity values changed from to m2 s−1 over the temperature range. The activation energies were found as 3.56, 3.71, and 3.86 kJ mol−1 at 25, 40, and 60°C, respectively. The experimental drying curves obtained were fitted to a three different models, namely, Peleg’s, first-order absorption kinetic, and exponential association equation models. All the models applied provided a good agreement with the experimental data with high values of the coefficient of determination (), the least values of the reduced chi-square (), and root mean square error (RMSE). Comparing the determination of coefficient, reduced chi-square, and root mean square error values of three models, it was concluded that the exponential association equation model represents swelling characteristics better than the others.
    01/2014; 2014:1-8. DOI:10.1155/2014/281063
  • Source
    • "Molecular imprinted hydrogels have attracted a great deal of attention over the last decade due to their potential to provide robust means for recognition of target analytes that is stable over long time [103,104]. In biosensors, we witnessed numerous implementations of such materials for direct refractometric-based detection of low molecular weight analytes relevant to medical diagnostics and environmental monitoring. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Hydrogel materials consisting of water-swollen polymer networks exhibit a large number of specific properties highly attractive for a variety of optical biosensor applications. This properties profile embraces the aqueous swelling medium as the basis of biocompatibility, non-fouling behavior, and being not cell toxic, while providing high optical quality and transparency. The present review focuses on some of the most interesting aspects of surface-attached hydrogel films as active binding matrices in optical biosensors based on surface plasmon resonance and optical waveguide mode spectroscopy. In particular, the chemical nature, specific properties, and applications of such hydrogel surface architectures for highly sensitive affinity biosensors based on evanescent wave optics are discussed. The specific class of responsive hydrogel systems, which can change their physical state in response to externally applied stimuli, have found large interest as sophisticated materials that provide a complex behavior to hydrogel-based sensing devices.
    12/2012; 2(1):40-69. DOI:10.3390/membranes2010040
Show more


34 Reads
Available from