Primary Role for CD4+ T Lymphocytes in Recovery from Oropharyngeal Candidiasis

Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane, Queensland, Australia.
Infection and Immunity (Impact Factor: 3.73). 03/2002; 70(2):724-31. DOI: 10.1128/IAI.70.2.724-731.2002
Source: PubMed


Oropharyngeal candidiasis is associated with defects in cell-mediated immunity and is commonly seen in human immunodeficiency
virus positive individuals and AIDS patients. A model for oral candidiasis in T-cell-deficient BALB/c and CBA/CaH nu/nu mice was established. After inoculation with 108 Candida albicans yeasts, these mice displayed increased levels of oral colonization compared to euthymic control mice and developed a chronic
oropharyngeal infection. Histopathological examination of nu/nu oral tissues revealed extensive hyphae penetrating the epithelium, with polymorphonuclear leukocyte microabscess formation.
Adoptive transfer of either naive or immune lymphocytes into immunodeficient mice resulted in the recovery of these animals
from the oral infection. Reconstitution of immunodeficient mice with naive CD4+ but not CD8+ T cells significantly decreased oral colonization compared to controls. Interleukin-12 and gamma interferon were detected
in the draining lymph nodes of immunodeficient mice following reconstitution with naive lymphocytes. This study demonstrates
the direct requirement for T lymphocytes in recovery from oral candidiasis and suggests that this is associated with the production
of cytokines by CD4+ T helper cells.

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