Gabapentin-Induced Worsening of Neuropsychiatric Symptoms in Dementia with Lewy Bodies: Case Reports

Istituto di Clinica delle Malattie Nervose e Mentali, Università 'La Sapienza', Roma, Italia.
European Neurology (Impact Factor: 1.36). 02/2002; 47(1):56-7. DOI: 10.1159/000047948
Source: PubMed
87 Reads
  • [Show abstract] [Hide abstract]
    ABSTRACT: The microbial community structure along an altitude gradient was investigated in different localities, in Kalasi lake, Urumqi river and Sangong river, Xingjiang (China). The mean numbers of DAPI (4',6-diamidino-2-phenylindole)-stained cells were lower in Kalasi lake than that in Urumqi river and Sangong river; these differences were attributed to increasing environmental harshness including lower soil organic carbon and nitrogen content, more acidic pH and lower annual temperature. In each locality, the numbers of bacteria and archaea measured with two fluorescence-labeled 16S rRNA oligonucleotide probes (EUB338 and ARCH915) were higher in a coniferous forest and lower in desert vegetation. A significant and positive relationship was found between microbial and soil organic carbon and total nitrogen along the altitudinal gradient, indicating that plant communities and soil nutrients influence the soil microbial structure. The results show that the microbial population in higher latitudinal site was fewer than lower latitudinal one, soil microorganisms were positively correlated to soil organic carbon and total nitrogen, and plant communities had an obviously impact on soil microbes.
    Folia Microbiologica 02/2004; 49(2):105-11. DOI:10.1007/BF02931382 · 1.00 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Behavioural and psychological symptoms of dementia (BPSD) have been defined as a heterogeneous range of psychological reactions, psychiatric symptoms and behaviours that may be unsafe, disruptive and impair the care of a patient in a given environment. To date, there are no US FDA-approved drugs or clear standards of pharmacological care for the treatment of BPSD. The novel antiepileptic agent gabapentin is being increasingly considered for use in the geriatric population because of its relatively favourable safety profile compared with other classes of psychiatric medications. Gabapentin has been administered to several geriatric patients with bipolar disorder and patients with dementia. It has also been reported to be successful in the treatment of a 13-year-old boy with behavioural dyscontrol, a finding that suggested a possible role for gabapentin in the treatment of other behavioural disorders. The purpose of this review was to find evidence for the use of gabapentin in the treatment of BPSD. To this end, a search was performed for case reports, case series, controlled trials and reviews of gabapentin in the treatment of this condition. The key words 'dementia', 'Alzheimer's disease' and 'gabapentin' were used. Searches were performed in PubMed, PsycINFO, Ovid MEDLINE, Cochrane Library and The search revealed that there are limited data on the efficacy of gabapentin for BPSD in the form of 11 case reports, 3 case series and 1 retrospective chart review; no controlled studies appear to have been published to date on this topic. In most of the reviewed cases, gabapentin was reported to be a well tolerated and effective treatment for BPSD. However, two case reports in which gabapentin was used in the context of agitation in dementia with Lewy bodies questioned the appropriateness of gabapentin for all types of dementia-related agitation. The dearth of available data limits support for the off-label use of gabapentin for the treatment of BPSD. Furthermore, controlled studies should be conducted before gabapentin can be clinically indicated for the successful treatment of BPSD.
    Drugs & Aging 02/2008; 25(3):187-96. DOI:10.2165/00002512-200825030-00002 · 2.84 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: In the present study, species composition, the contribution of major groupings to community structure, and diversity level (species richness, heterogeneity, and evenness) were examined in their distribution in a soil depth of 0 – 43 cm in two opposite slopes at “Evolution Canyon” I, Nahal Oren, Mount Carmel, Israel. A total of 90 species from 35 genera belonging to Zygomycota (2 species), teleomorphic Ascomycota (12), and anamorphic Ascomycota (76) were isolated. In the soil profile of the xeric “African” south-facing slope (AS), melanin-containing fungi and teleomorphic species remarkably decreased their abundance with depth, while Penicillium spp. and Aspergillus spp. increased their contribution to the community structure. These variations were accompanied by a decrease in heterogeneity and evenness of the microfungal communities. In contrast, on the mesic “European” north-facing slope (ES), a sharp decrease in abundance of penicilli was observed with soil depth, followed by increasing diversity level of the communities. The variations in community structure through soil profiles were associated with variations in edaphic conditions (increasing soil moisture) together with escape from solar radiation on the AS and a decrease of organic matter content on the ES.
    Plant Biosystems 03/2008; 142(1-1):51-59. DOI:10.1080/11263500701872325 · 1.92 Impact Factor
Show more