Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization.

Department of Pharmacology and Molecular Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Neuron (Impact Factor: 15.98). 02/2002; 33(3):321-4. DOI: 10.1016/S0896-6273(02)00585-8
Source: PubMed

ABSTRACT The Notch signaling pathway plays a role in cell fate specification in many metazoans. A critical aspect of Notch activation involves proteolysis of the Notch receptor. This cleavage event requires Presenilin as a component of a large multiprotein complex, gamma-secretase. This complex mediates a similar cleavage event of the beta-amyloid precursor protein (APP). The transmembrane protein Nicastrin has been found to associate with Presenilin, Notch, and APP. Recent biochemical and genetic studies have focused on elucidating the function of this protein.

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