Acute scleral thinning after pterygium excision with intraoperative mitomycin C: a case report of scleral dellen after bare sclera technique and review of the literature
ABSTRACT To describe a patient with scleral dellen after pterygium excision with intraoperative mitomycin C.
Case report and MEDLINE review of the medical literature on scleral dellen after bare sclera technique.
A 48-year-old man had a left nasal pterygium excised by the bare sclera technique with intraoperative mitomycin C. Eight days after surgery, the patient noticed a small black spot in the bare sclera area with mild irritation. Slit-lamp examination revealed a focal area of extreme thinning, centered on the nonepithelialized bare sclera, surrounded by edematous conjunctiva. The ciliary body was visible through the thin and dry scleral lesion. After topical lubricant therapy, the scleral lesion appeared normal thickness and white in color 3 days later. Therapy was continued until the sclera epithelialized.
Scleral dellen is an early postoperative complication of bare sclera technique owing to delayed conjunctival wound closure. Hydration of the thinned sclera will rapidly thicken it. However, medical therapy should be continued until the surrounding conjunctiva has flattened and the sclera has epithelialized. Surgical wound closure is an alternative management and may be the way to prevent scleral dellen formation after bare sclera technique. All patients after bare sclera surgery should be followed up until the conjunctival wound has healed. If delayed healing is found, frequent artificial tears, patching, or surgical intervention is necessary.
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- "We think that relatively small sample sizes are an important factor causing differences in the reports. Complications as keratitis, corneal endothelial changes, scleral thinning and melting may occur also with intraoperative MMC (Tsai 2002; Safianik et al. 2002; Zhivov et al. 2009; Peponis et al. 2009). We experienced only one serious complication in this group, a corneascleral melting which was managed by lamellar corneal graft. "
ABSTRACT: To compare the 4-year outcome of primary pterygium excision using intraoperative mitomycin C (MMC) with suturing a free conjunctival autograft (CA). A total of 115 eyes with nasal primary pterygium of 115 patients were included in the study. After randomization into two groups, the eyes were operated on by a single surgeon (GK). After excision of the pterygium, 56 eyes received 0.04% MMC intraoperatively on the bare sclera for 3 min and 59 eyes received a free CA sutured using 7-0 Vicryl. Postoperative follow-up was 4 years. Main outcome measures were recurrences, re-operations, surgery time, complications, visual acuity and astigmatism. Statistical evaluation was performed with the chi-squared test. The recurrence rate was 38% in the MMC group and 15% in the CA group (p < 0.05). The re-operation rate of the recurrences was 53% in the MMC group and 29% in the CA group. Average surgery time was 13 minutes (range: 6-22 min) in the MMC group and 26 min (range: 18-32 min) in the CA group (p < 0.01). There was no significant change in best-corrected visual acuity and astigmatism. One major complication occurred in each group. The most frequently observed complication was delayed epithelial healing (40%) and mild scleral thinning (20%) in the MMC group and suture-related inflammation in the CA group (10%). Pterygium surgery including free autologous conjunctival grafting is associated with fewer recurrences, re-operations and complications than using the bare sclera technique together with single-dose intraoperative MMC.Acta ophthalmologica 05/2010; 90(3):266-70. DOI:10.1111/j.1755-3768.2010.01936.x · 2.51 Impact Factor
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ABSTRACT: To report a case of excimer laser phototherapeutic keratectomy retreatment of anterior basement membrane (ABM) dystrophy and Salzmann's nodular degeneration with a single intraoperative application of topical mitomycin C (0.02%). Case report. A 91-year-old woman underwent excimer laser phototherapeutic keratectomy (PTK) in the left eye for ABM dystrophy and Salzmann's nodular degeneration causing decreased visual acuity (VA), ocular irritation, and recurrent erosions. Slit-lamp examination of both eyes revealed diffuse ABM dystrophy changes with mild to moderate subepithelial and anterior stromal haze and scarring involving the visual axis. The PTK treatment was preceded by a superficial keratectomy with a blade. The excimer laser was set for a 6-mm circular ablation zone with a treatment depth of 5 microm. The cornea remained clear for several months. Six months after surgery, the patient presented with difficulty reading and VA of 20/70. Slit-lamp examination of the left eye revealed recurrent Salzmann-type nodular degeneration inferior to the visual axis. A treatment course of topical steroids was not successful. She underwent another superficial keratectomy with a blade and PTK treatment (same laser parameters as the first procedure) with a 2-minute application of 0.02% mitomycin C on a cellulose sponge. The surgery proceeded without complications. On postoperative day 7, she presented with a healed epithelium and faint anterior stromal haze. Best-corrected visual acuity was 20/50, which is her best-expected VA. Six months after the procedure, the cornea revealed no signs of recurrence. The use of topical mitomycin C in conjunction with PTK may prevent recurrence of Salzmann's nodular degeneration.Cornea 12/2002; 21(8):828-30. DOI:10.1097/00003226-200211000-00020 · 2.36 Impact Factor
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ABSTRACT: To compare the effect of a 3- and 5-minute intraoperative application of topical mitomycin C 0.02% on the recurrence of pterygium. A comparative, prospective clinical design was used. The study population consisted of 134 consecutive patients with unilateral primary advanced pterygium (growth of 3 mm or more horizontally from the limbus). All underwent excision of the lesion, leaving the sclera bare. At completion of surgery, topical mitomycin C 0.02% was applied for 3 minutes in the first 60 patients (group A) and for 5 minutes in the remaining 74 patients (group B). The patients were followed for 26 months by slit-lamp biomicroscopic examination of the anterior segment. Recurrent pterygium was defined as the postoperative appearance of a fibrovascular tissue crossing the limbus. After 12 months of follow-up, pterygium recurred in 20 patients (33.3%) in group A and in two patients (2.7%) in group B. After 15 months, the recurrence rates were 36.6% and 5.4%, respectively, and remained unchanged at 26 months. There were no cases of drug toxicity in either group. Five-minute intraoperative application of a single dose of 0.02% mitomycin C is safe and more effective than a 3-minute application in recurrence of pterygium.Cornea 04/2003; 22(2):102-4. DOI:10.1097/00003226-200303000-00003 · 2.36 Impact Factor