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Chung JY, Park YC, Hong Y and Wu HAll TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. J. Cell Sci. 115: 679-688

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.
Journal of Cell Science (Impact Factor: 5.33). 03/2002; 115(Pt 4):679-88.
Source: PubMed

ABSTRACT The tumor necrosis factor (TNF) receptor associated factors (TRAFs) have emerged as the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1R/TLR) superfamily. TRAFs collectively play important functions in both adaptive and innate immunity. Recent functional and structural studies have revealed the individuality of each of the mammalian TRAFs and advanced our understanding of the underlying molecular mechanisms. Here, we examine this functional divergence among TRAFs from a perspective of both upstream and downstream TRAF signal transduction pathways and of signaling-dependent regulation of TRAF trafficking. We raise additional questions and propose hypotheses regarding the molecular basis of TRAF signaling specificity.

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    • "IRE1α plays a critical role in transcription of inflammatory genes due to its interaction with TRAF2, which promotes NF-κB activation and inflammatory response. The TRAF family proteins are intracellular adaptors that have been extensively studied in the signaling pathways of TNFR or IL-1/TLR super-families (Chung et al., 2002; Oganesyan et al., 2006; Bishop et al., 2007). All TRAF family proteins (TRAF1-7) have the most conserved TRAF domains in their carboxyl terminal region, which involve in binding to different receptor cytoplasmic tails and the formation of homo- or hetero-dimers between the family members. "
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    Frontiers in Genetics 07/2014; 5:242. DOI:10.3389/fgene.2014.00242
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    • "TNF receptor-associated factors (TRAF) play a major role in linking the TNF receptor to downstream signaling pathways [23]. However, TRAF2 has also been reported to be essential for PKC-dependent NF-κB signaling and JNK activation [24], [25], [26], [27]. "
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    PLoS ONE 02/2014; 9(2):e89479. DOI:10.1371/journal.pone.0089479 · 3.23 Impact Factor
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    • "TRAFs collectively play important roles, including actions in adaptive and innate immunity, embryonic development, the stress response and bone metabolism. These functions are mediated by TRAFs through the induction of cell survival, proliferation, differentiation and death (3–8). "
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