"Pulmonary blastomycosis can present in a manner indistinguishable from bacterial pneumonia, tuberculosis, or bronchogenic carcinoma.23 The relatively low isolation rate noted in the present study and other reports may be a result of blastomycosis being misdiagnosed and difficult to identify in the diagnostic laboratories. "
[Show abstract][Hide abstract] ABSTRACT: One hundred and fifty immunocompetent and 150 presumably immunocompromised patients suffering from lower respiratory tract infections were enrolled in this study. The clinical specimens were collected from April 2007 to June 2008 and included sputum (247), bronchial wash (80), and blood (300) samples. The identification process employed direct examination, culture, conversion test, and serological study. Among 218 fungal isolates only six were categorized as true pathogenic fungi; two Histoplasma capsulatum, and four Blastomyces dermatitidis. The former isolates were detected in two immunocompromised patients, while the latter isolates were detected in two immunocompetent and two immunocompromised patients.
[Show abstract][Hide abstract] ABSTRACT: A chronically implantable neural information transducer is being developed for physiological and clinical applications. The technology is based on microfabricated silicon structures which can eventually integrate signal processing circuitry on the same substrate. The micromachined probe structure has been optimized for biocompatibility. Fabrication and design aspects of the probe which determine the ultimate signal to noise ratio of the system have been identified and are being optimized. A sensor and analytical technique for non-destructive assessment of thin film passivation layers has been identified and will be used to develop passivation technology for chronically implantable neural information sensors.
Electron Devices Meeting, 1986 International; 02/1986
[Show abstract][Hide abstract] ABSTRACT: Clinically, blastomycosis can be difficult to recognize even in the endemic areas where clinicians are aware of this problem. In only 18% of 123 patients from the University of Mississippi Medical Center (Jackson, MS) blastomycosis was correctly suspected at the initial patient evaluation. Pneumonia sensu latu (40%), malignant tumors (16%), and tuberculosis (14%) were the most common misdiagnoses. The false first impression frequently resulted in unnecessary surgeries or treatment delays, with patients receiving inefficient antibiotic therapy for months. The presence of cutaneous involvement by the disease makes its' recognition easier for the clinician, raising the percentage of correct initial diagnosis to 64%. To evaluate the association with immunodepression, the presence of other diseases was also searched among the 123 patients. An immunodepressive condition preceded the fungal disease in 25% of patients. Another associated disease commonly found in blastomycotic patients was diabetes mellitus (22%). Blastomycosis is correctly suspected at the first clinical evaluation in only a small percentage of patients; pneumonia, cancer, and tuberculosis are the most common clinical considerations. Cutaneous involvement leads the clinician to the correct diagnosis in the majority of cases. One fourth of the patients with blastomycosis had underlying immunodepressive conditions, and underlying diabetes mellitus is present in 22% of patients.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.