Symptomatic dietary vitamin B-12 deficiency in a nonvegetarian population

Ben-Gurion University of the Negev, Be'er Sheva`, Southern District, Israel
The American Journal of Medicine (Impact Factor: 5.3). 05/2002; 112(5):413-6. DOI: 10.1016/S0002-9343(02)01031-8
Source: PubMed
  • Source
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Nutrient deficiencies are prevalent worldwide. Diseases and morbid conditions have been described to result from nutritional deficiencies. It is essential to address nutrient deficiencies as these may lead to chronic long-term health problems such as rickets, iron deficiency anemia, goiter, obesity, coronary heart disease, type 2 diabetes, stroke, cancer and osteoporosis. In the present review we surveyed the extent and severity of nutritional deficiencies in Israel through a selective and comprehensive Medline review of previous reports and studies performed during the last 40 years. Israeli populations have multiple nutritional deficiencies, including iron, calcium, zinc, folic acid, and vitamins B12, C, D and E, spanning all age groups, several minorities, and specific regions. In Israel, some of the nutrients are mandatorily implemented and many of them are implemented voluntarily by local industries. We suggest ways to prevent and treat the nutritional deficiencies, as a step to promote food fortification in Israel.
    05/2014; 2(5):120-125. DOI:10.12998/wjcc.v2.i5.120
  • [Show abstract] [Hide abstract]
    ABSTRACT: Purpose. – The aim of this study was to describe the present clinical characteristics of the pernicious anemia (PA).Method. – It is a retrospective (1996–2002) multicenter (five departments of internal medicine) study of 49 patients presenting an established cobalamin deficiency related to PA.Results. – The median age of the patients was 74 years (25–93), the female/male ratio 2:9. Several autoimmune disorders were noted in 35% of the patients. Various clinical manifestations, mainly neurological, cutaneous and thrombotic, were found in 65.4% of the patients, at least one hematological abnormalities in 100%. Average serum vitamin B12 and homocystein levels were with 73 pg/ml (20–1960) and 42.9 μmol/l (7, 8–124). Anti-intrinsic factor or anti-parietal gastric cells antibodies were found in 87.5% and 62% of the patients (at least one antibody, in 96%) abnormal Schilling’s test results in 86%. All the followed patients were successful treated with intramuscular (n = 27) or oral crystalline cyanocobalamin (n = 5).Conclusions. – PA was associated with several autoimmune disorders; PA may be responsible of various clinical manifestations or biological abnormalities; and oral crystalline cyanocobalamin treatment may be successful.
    La Revue de Médecine Interne 08/2004; 25(8):556-561. DOI:10.1016/j.revmed.2004.03.008 · 1.32 Impact Factor