Article

Nazarov reagents for convergent and expedient synthesis of new steroids.

Laboratoire de synthèse organique, Institut de pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4.
Organic Letters (Impact Factor: 6.14). 05/2002; 4(7):1091-4. DOI: 10.1021/ol017274r
Source: PubMed

ABSTRACT [reaction: see text] A new methodology for the convergent synthesis of tetracyclic compounds was developed. Two new bicyclic Nazarov reagents of type II were synthesized, and their cycloaddition with 2-carbomethoxy-2-cyclohexenone I was studied. This cycloaddition afforded new interesting steroidal backbones.

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