Article

Lack of normal structural asymmetry of the anterior cingulate gyrus in female patients with schizophrenia: A volumetric magnetic resonance imaging study

Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
Schizophrenia Research (Impact Factor: 4.43). 06/2002; 55(1-2):69-81. DOI: 10.1016/S0920-9964(01)00200-6
Source: PubMed

ABSTRACT We investigated anterior cingulate gyrus (ACG) volume in 40 patients with schizophrenia (20 males, 20 females) and 40 age-and sex-matched normal controls using three-dimensional magnetic resonance imaging (MRI). Volumes of the whole brain and both the gray and white matter of the ACG were measured on consecutive coronal 1-mm slices. There was no significant difference between the patients with schizophrenia and the normal controls in the whole brain volume. Right ACG gray matter volume was significantly reduced in the female patients with schizophrenia as compared with the female controls. Furthermore.in the female controls, ACG gray matter volume was significantly larger on the right than on the left, while this asymmetry was not significant in the female patients. ACG white matter findings were similar to those of the ACG gray matter in that the volume was significantly larger on the right in the female controls, and this normal structural asymmetry was reduced in the female patients. These results suggest that gender may play an important role in the structural asymmetry anomalies in schizophrenia.

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    • "Stereological volumetric assessment of the AC grey matter volume was conducted using the MEASURE program and Cavalieri method (Barta et al., 1997), adopting the identification procedure described by Takahashi et al. (2002) (Figure 1). All AC grey matter volumes ratings, separately for the left and right hemispheres, were performed by a single trained rater (SU), who had high intra-and inter-rater (against PP, an experienced MEASURE rater) reliabilities and was kept blind to participant group membership to avoid any observer bias in rating results. "
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