Spider-mite allergy and asthma in fruit growers.
ABSTRACT Asthma and allergic diseases caused by domestic mites such as house dust mites and storage mites are major health problems worldwide. In contrast to domestic mites, spider mites are outdoor phytophagous mites causing significant damage to fruit leaves throughout the world. After several case reports of spider mite-induced asthma and allergy, cross-sectional surveys have demonstrated that spider mites are important allergens in the development of asthma and rhinitis in fruit farmers. Interestingly, epidemiological surveys have also demonstrated that spider mites are common sensitizing allergens that are related to the prevalence of asthma and rhinitis, even in the non-farming population exposed to spider mites. Protein analysis has demonstrated that crude extracts derived from spider mites contain several major allergens, and that N-terminal amino acid sequencing of the major allergens is not homologous with any previously characterized domestic mite allergens, suggesting that major allergens derived from spider mites are unique in terms of cross-reactivity to domestic mites. Taken together, these findings suggest that spider mites are important allergens in the development of asthma among the exposed non-farming population as well as among fruit farmers themselves, and that allergens derived from spider mites may be novel allergens.
SourceAvailable from: Mohamed Jeebhay[Show abstract] [Hide abstract]
ABSTRACT: Recent studies among farm workers suggest that excessive pesticide use as well as biological factors such as outdoor mites may be responsible for asthma symptoms experienced by workers. Grape farms, in contrast to fruit farms, have not been previously investigated for occupational respiratory allergy to spider mites. A cross-sectional study was conducted on 207 workers employed in nine table grape farms, investigating allergic sensitisation to common inhalants and occupational allergens. Common work-related symptoms included wheezing (26%), rhino-conjunctivitis (24%), urticaria/skin symptoms (15%) and doctor diagnosed asthma present in 9% of subjects with work-related symptoms. These work-related symptoms were significantly higher (p<0.001) in the orchards compared to the stores. The highest prevalence of positive skin prick tests was observed to spider mite (T. urticae) with 23%, followed by HDM (D. Pteronyssinus) with 16% and cockroach (B. germanica) with 12%. This study has demonstrated that spider mites such as Tetranychus urticae may be important outdoor allergen responsible for allergic symptoms among table grape farm workers in the Western Cape province of South Africa.Current Allergy and Clinical Immunology 01/2002; 15(4):174-177. DOI:10.13140/2.1.3403.3284 · 0.15 Impact Factor
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ABSTRACT: Objectives Occupational asthma remains relatively under-recognized in India with little or no information regarding preventable causes. We studied occupations with an increased prevalence of self-reported asthma among adult men and women in India. Methods Analysis is based on 64 725 men aged 15–54 years and 52 994 women aged 15–49 years who participated in India’s third National Family Health Survey, 2005–2006, and reported their current occupation. Prevalence odds ratios (ORs) for specific occupations and asthma were estimated using multivariate logistic regression, separately for men and women, adjusting for age, education, household wealth index, current tobacco smoking, cooking fuel use, rural/urban residence and access to healthcare. Results The prevalence of asthma among the working population was 1.9%. The highest odds ratios for asthma were found among men in the plant and machine operators and assemblers major occupation category (OR: 1.67; 95% CI: 1.14–2.45; p = 0.009). Men working in occupation subcategories of machine operators and assemblers (OR: 1.85; 95% CI: 1.24–2.76; p = 0.002) and mining, construction, manufacturing and transport (OR: 1.33; 95% CI: 1.00–1.77; p = 0.051) were at the highest risk of asthma. Reduced odds of asthma prevalence in men was observed among extraction and building trades workers (OR: 0.72; 95% CI: 0.53–0.97; p = 0.029). Among women none of the occupation categories or subcategories was found significant for asthma risk. Men and women employed in high-risk occupations were not at a higher risk of asthma when compared with those in low-risk occupations. Conclusions This large population-based, nationally representative cross-sectional study has confirmed findings from high income countries showing high prevalence of asthma in men in a number of occupational categories and subcategories; however, with no evidence of increased risks for women in the same occupations.Journal of Asthma 05/2014; 51(8). DOI:10.3109/02770903.2014.913619 · 1.83 Impact Factor
Allergologie 01/2012; 35. DOI:10.5414/ALX01493 · 0.30 Impact Factor