Dose–response effects of a novel fat emulsion (Olibra™) on energy and macronutrient intakes up to 36 h post-consumption

The Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, Co Londonderry, Northern Ireland, UK.
European Journal of Clinical Nutrition (Impact Factor: 2.95). 04/2002; 56(4):368-77. DOI: 10.1038/sj.ejcn.1601326
Source: PubMed

ABSTRACT To investigate the dose-response effects of a novel fat emulsion (Olibra) on energy and macronutrient intakes up to 36 h post-consumption in non-overweight subjects.
A single-blind, placebo-controlled, within-subject cross-over design was used.
Metabolic suite of the University of Ulster, Coleraine.
Fifty subjects (30 female, 20 male) from the student and staff population of the University of Ulster, Coleraine.
Subjects were given in random order, 7 days apart, a 200 g portion of yoghurt containing a total of 15 g of fat, which varied in quantity of Olibra fat (0, 2, 4, 6 g) at 09:00 h. At 13:00 h subjects were given ad libitum access to a range of foods. Amounts of food consumed were measured by covert pre- and post-consumption weighing of individual serving dishes. For the remainder of the day and the following 24 h, subjects weighed and recorded all food intakes.
Relative to the control yoghurt, mean energy (7.42 vs 5.83, 5.60, 5.24 MJ), fat (97.4 vs 74.4, 74.2, 67.5 g; 48.8 vs 46.8, 48.9, 47.6% energy), protein (59.1 vs 50.0, 44.0, 40.8 g; 13.2 vs 13.9, 12.9, 12.8% energy), and carbohydrate (171.5 vs 140.9, 130.2, 126.0 g; 38.0 vs 39.3, 38.2, 39.6% energy), intakes were progressively reduced with increasing doses of Olibra fat in the total group (P<0.001). A similar response was observed in the female group up to 4 g (P<0.001) and in the male group after 2 and 6 g (P<0.05). Energy and macronutrient intakes for the remainder of each study day and over the following 24 h were significantly lower after all dose levels compared to the control (P<0.001).
The results suggest that Olibra fat reduced the effect of overeating during an ad libitum lunch meal and subsequent food intake up to 36 h post-consumption.

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    • "It is produced by Lipid Technology Provider (LTP, Sweden) and marketed for satiety benefits in food applications by DSM (The Netherlands). Initial published research, performed in one laboratory by the same research group, reported significant decreases in energy and macronutrient intakes 4-8h post-treatment when Fabuless™, compared to a control fat, was added to yoghurt (Burns et al., 2000; 2001), and that these effects were dose-dependent (Burns et al., 2002). However, no subsequent studies have replicated these initial results. "
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    • "The relatively long (N3 h) time lapse between the preload and the outcome meal may make changes in eating behaviour more difficult to induce than trials employing a shorter timeframe. It is also possible that the buffet-style lunch, whilst restricted to only a few items, may have encouraged over-consumption , decreased sensitivity and masked differential effects, but again it is notable that a multi-item buffet lunch has previously been shown to be sensitive to effects of acute lipid manipulations [3] [4] [5]. A prior study conducted in our laboratory has also shown it to be sensitive to changes in energy content at a breakfast meal [33]. "
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    • "The higher body weight, and thus higher energy requirement (9.7 MJ/day for the junior-normal weight compared to 10.0 MJ/day for the senior-overweight subjects) [17], of the senior-overweight subjects is an explanation for this. What are the differences between our present study and the Burns studies that showed a significant lower EI compared to control after consumption of yoghurt containing the novel fat emulsion in nonoverweight , overweight and obese subjects [5] [6] [7]? Not the design: both studies were double-blind, placebo-controlled, with a withinsubject crossover design. "
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