Measles antibody prevalence rates among young adults in Israel.
ABSTRACT In Israel, vaccination coverage against measles is high, yet seroepidemiologic studies have shown that more than 15% of the 18-year-old population were unprotected against the disease. A 2-dose program of vaccination against measles, mumps, and rubella at the ages of 1 and 6 years was begun in 1990, supplemented by a measles catch-up plan for all 13-year-olds. The aim of this study was to assess the prevalence of antimeasles antibodies at induction to the Israel Defense Forces in the first doubly vaccinated birth-cohort.
In 1996, serum samples of 540 recruits, 339 men and 201 women, were tested for measles virus antibody. Findings were compared with surveys conducted in 1987 and 1990.
Measles antibodies were present in 95.6% (95% CI, 93.5-97.1) of the recruits. Antibody prevalence was higher in women than in men (99% vs 93.5%; P =.0096). A slightly lower seroprevalence was found in recruits born in the former Soviet Union. The results were substantially higher than the seroprevalence rates found in 1987 (73.3%) and 1990 (84.6%).
The high prevalence of antimeasles antibodies in the young adult population in Israel points to the success of the double-vaccination policy in promoting immunity against the disease.
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ABSTRACT: Aims: A survey was conducted amongst university students to assess their level of susceptibility to and knowledge about measles, mumps and rubella (MMR) and their prevention, and to find factors associated to their seropositivity for MMR viruses. Subjects, and methods: A cross-sectional study was conducted involving 961 students from the University of Cassino (Italy). The enzyme immunoassay method was used to assess seropositivity for MMR, while knowledge and previous vaccination information were acquired through a self-administered questionnaire. Results: The prevalence of IgG antibodies was 93.2% for measles, 91.4% for mumps and 81.3% for rubella. The susceptibility for measles was higher in the 21–25 and over 31 age groups. The seroprevalence profile of mumps was similar to that of measles, while the level of immunity to rubella was very low in students aged under 20 years (76.7%) and 21–25 years (81.2%). Only 111 students said they had been vaccinated against measles, 46 against mumps and 103 against rubella. Most students demonstrated poor knowledge concerning MMR and were not practicing preventive behaviours. Conclusions: The susceptibility was particularly high for rubella. Concerted efforts are needed to educate young adults about the benefits of vaccination and to raise their level of consciousness so as to motivate them to request vaccination.Journal of Public Health 10/2010; 18(5). DOI:10.1007/s10389-010-0324-z · 2.06 Impact Factor
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ABSTRACT: Background: Measles is a vaccine preventable infectious disease. Despite the widespread availability of an effective measles vaccine, the number of measles cases is noticeable in Iran. Because measles –specific antibody titer after vaccination is lower than after naturalinfection there is a concern that vaccinated persons may gradually lose protection from measles. This study was performed to examine the persistence of vaccine-induced antibody, participants with documented history of vaccination were assessed to determine thesero-prevalence and titer of measles antibody.Methods: This study was carried out in Urmia. Iran. Documented history of at least a single dose of live attenuated measles vaccine (at 9 or 15 month of age) was the inclusion criteria.Blood was collected from 835 subjects between 5 and 25 years old. The sera were tested for anti-measles IgG antibodies, by ELISA (IBL Germany). Associations between predictive factors such as demographic data, vaccination status (once or twice) with IgGsero prevalence in routine vaccinated subjects were investigated by logistic regression analysis.Results: The antibody titers in 54.76% of cases were in the range of protective level (IgG>12IU). The mean of antibody titer significantly increased after the 16th year of life.The antibody titers were higher in participants who received one dose of measles vaccine in comparison with the persons who received a booster of measles vaccine. Antibody titers were slightly higher in men than in women. On multiple logistic regression analysis, of all variables examined, only vaccination status retained a significant association with antimeasles sero-positivity rate (estimated odds ratio = 0.395 95% CI = 0.214-0.859, P<0.05).Conclusion: Elevation of antibody titer many years after vaccination is most likely due to boosting effect from repeated exposure to circulating wild virus resulting in unapparent or sub-clinical re-infection. This group of persons would be the most likely to support viral transmission in the absence of disease.