Physical impairment and social life goals among adult long-term survivors of childhood cancer: a population-based study from the childhood cancer registry of Piedmont, Italy.
ABSTRACT The study describes the health status and the attainment of life goals in the adult survivors of childhood cancer recorded at the Childhood Cancer Registry of Piedmont.
A postal questionnaire was sent to the general practitioner of the 690 cases born before 1976 and alive in 1991 after at least 5 years from diagnosis. The answer was received for 485 (72.9%) included in the analyses. Items in the questionnaire were: sequelae related to cancer and its treatment, health-related quality of life (according to Bloom's criteria), educational level attained, and employment status.
Vital and marital status were obtained for all 690 cases at the offices of the town of residence. No medical condition was reported for 309 cases (63.7%). The overall proportion with a high school or university education was compared to corresponding figures for Piedmont in 1991, adjusted by age, and was as high as in the general population. Similar results are observed for occupation. Patients of both genders were married less than expected. Patients with leukemia (112 cases), non-Hodgkin's lymphoma (34) or Hodgkin's lymphoma (52) were reported to have the highest quality of life. In contrast, patients with tumors of the central nervous system (151) had the highest frequency of sequelae and the lowest score for health-related quality of life. They-also presented the lowest educational achievement, the lowest proportion of employment and, among males, the lowest frequency of marriage.
Our study shows a good social adjustment of adult survivors from childhood cancer, with the exception of central nervous system tumors. From the methodologic point of view, the present study shows the feasibility of surveillance surveys on health-related quality of life with the contribution of general practitioners.
Article: Surviving Childhood Cancer[Show abstract] [Hide abstract]
ABSTRACT: With modern therapies, most children diagnosed with cancer are expected to reach adulthood. Therefore, there are large and ever-increasing numbers of children and young adults in our population who are survivors of childhood cancer. Many of the therapies responsible for improved cancer survival rates can also damage normal cells and tissues. As more children survive cancer, the physical and emotional costs of enduring cancer therapy become increasingly important. Although most childhood cancer survivors are now expected to survive, they remain at risk for relapse, second malignant neoplasms, organ dysfunction, and a negative psychologic impact. Individual risk is quite variable and is dependent on multiple factors including the type and site of cancer, the therapy utilized, and the individual’s constitution. The risks are likely to change as we learn more about the specific long-term effects of cancer therapy, develop more refined and targeted therapies, and develop and apply more effective preventative strategies or therapeutic interventions. Guidelines for long-term follow-up have been established and are available to help facilitate appropriate monitoring of and care for potential late effects.Paediatric Drugs 11/2002; 8(2). · 1.72 Impact Factor
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ABSTRACT: Partnerships and parenthood can have important effects on economic, social and psychological well-being. We provide new long-term analysis of how disability affects both parental status and partnerships. Analysis of the new Life Opportunities Survey, which is based on social model approaches, demonstrates that disabled people are more likely than non-disabled people to face disadvantages in terms of family formation. Disabled people are more likely to remain single over time, although there is less evidence for any differences in rates of relationship breakdown for those who enter them. Allied to these conclusions, disabled adults are less likely to form households where there are dependent children. These conclusions are supported by longitudinal results from the British Household Panel Survey.Disability & Society 01/2014; 29(4). · 0.73 Impact Factor
Article: Young Survivors of Childhood Cancer[Show abstract] [Hide abstract]
ABSTRACT: Due to recent advances in new and successful treatments the consequences of receiving a diagnosis of cancer in childhood have dramatically changed. Children and adolescents with cancer, who may have had a limited life expectancy a few decades ago, are now often surviving into adulthood. The overall five-year survival was over 72% for all pediatric malignancies in 19 European countries in the period 1978−1997 . In the UK, the overall survival was 75% between 1992 and 1996  with the highest survival for survivors of Hodgkin’s disease (95%) and retinoblastoma (95%) and the lowest for primitive neuroectodermal tumors (50%) and neuroblastoma (55%). The overall survival in the US was 80% in the period 1996−2003 compared to 62% in 1975–1977 . The highest survival rates in the US were found for survivors of Hodgkin’s disease (95%) and Wilm’s tumor (92%), while the lowest survival rate of 50% was found for survivors of acute myeloid leukemia .