Article

Remodeling of arterial conduits in coronary grafting.

Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
The Annals of Thoracic Surgery (impact factor: 3.74). 05/2002; 73(4):1341-5. pp.1341-5
Source: PubMed

ABSTRACT In the initial decade of coronary surgery, serial angiography of internal thoracic artery grafts revealed increased caliber in some, decreased caliber in others, and "string sign" in a few, which was occasionally documented to be reversible. Although we speculated on possible causes of these changes, it was not until discovery of the endothelial role in modulating arterial diameter to maintain shear stress in a narrow range that we began to gain insight into the mechanisms responsible for remodeling of the arterial wall. This review provides a glimpse of the physiology and biology of arterial remodeling and summarizes observations on the various arterial conduits when subjected to flow alterations.

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Keywords

arterial
 
arterial wall
 
endothelial role
 
flow alterations
 
initial decade
 
internal thoracic artery grafts
 
mechanisms responsible
 
modulating arterial diameter
 
narrow range
 
physiology
 
serial angiography
 
shear stress
 
string sign
 
various arterial conduits