Erinacine Q, a new erinacine from Hericium erinaceum, and its biosynthetic route to erinacine C in the basidiomycete.
ABSTRACT Erinacines as cyathane-xylosides are known to have potent stimulating activity for nerve-growth-factor synthesis. Our search for new cyathane metabolites from a liquid culture of Hericium erinaceum YB4-6237 resulted in the isolation of a new erinacine named erinacine Q (1). NMR spectrometry and a chemical derivation from erinacine P (2) determined the compound to be a derivative in which the formyl group of erinacine P had been reduced to the hydroxymethyl group. To clarify the biosynthetic relationship between erinacine Q and the others, [1'-13C]erinacine Q ([1'-13C]-1) was chemically derived from [1'-13C]erinacine P ([1'-13C]-2) which had been prepared by feeding [1-13C]-D-glucose to the basidiomycete. The biotransformation of labeled erinacine Q into [1'-13C]erinacine C ([1'-13C]-5) via [1'-13C]erinacine P in this basidiomycete was demonstrated by NMR spectrometry.
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ABSTRACT: Helicium erinaceus (HE) is a fungal mushroom habiting in the mountainous areas of northeast territories. HE has been used in the traditional folk medicines and medicinal cuisine in China, Korea and Japan. It has been implicated in a variety of physiological functions such as anti-aging, anti-cancer, anti-gastritis, anti-metabolic diseases, etc. Hence, HE is an attractive target resource for developing not only medicines but also functional foods. Basic studies on the physiological functions and the chemical identification of its active ingredients have progressed in recent decades. In this article, we provide an overview of the biochemical and pharmacological studies of HE, especially of its antitumor and neural preserving functions, together with recent developments in the chemical analysis of its polysaccharides which comprise its major active components.10/2014; DOI:10.1039/C4FO00511B