Article

Inhibition of Na+/Ca2+ exchange by hexapeptide FRCRSFa in rat ventricular myocytes.

Department of Cardiology, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Acta Pharmacologica Sinica (impact factor: 1.95). 07/2002; 23(6):529-33. pp.529-33
Source: PubMed

ABSTRACT To study the effect of Phe-Arg-Cys-Arg-Ser-Phe-CONH2 (FRCRSFa) on Na+/Ca2+ exchange and its specificity in rat ventricular myocytes.
Na+/Ca2+ exchange current (INa+/Ca2+) and other currents were measured using whole-cell voltage clamp technique.
A concentration-dependent inhibition of hexapeptide FRCRSFa on Na +/Ca2+ exchange was observed in rat ventricular myocytes. IC50 of inward and outward INa+/Ca2+ were 2 and 4 micromol/L, respectively. FRCRSFa 5 micromol/L did not affect L-type Ca2+ current, voltage-gated Na+ current, transient outward K+ current, and inward rectifier K+ current.
These data indicate that FRCRSFa is an available inhibitor of Na+/Ca2+ exchange with relative selectivity and m ay be valuable for studies of the Na+/Ca2+ exchange in cardiac myocytes.

0 0
 · 
0 Bookmarks
 · 
21 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

4 micromol/L
 
currents
 
FRCRSFa
 
FRCRSFa 5 micromol/L
 
hexapeptide FRCRSFa
 
inward
 
inward rectifier K+ current
 
Na +/Ca2+ exchange
 
Na+/Ca2+ exchange
 
Na+/Ca2+ exchange current
 
outward INa+/Ca2+
 
rat ventricular myocytes
 
relative selectivity
 
transient outward K+ current
 
voltage-gated Na+ current
 
whole-cell voltage clamp technique
 

Qing-Hua Han