Determination of irbesartan in the presence of hydrochlorothiazide by derivative spectrophotometry.

Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071 Murcia, Spain.
Journal of Pharmaceutical and Biomedical Analysis (Impact Factor: 2.95). 07/2002; 29(1-2):299-305. DOI: 10.1016/S0731-7085(02)00073-0
Source: PubMed

ABSTRACT A first-derivative spectrophotometric method for the determination of irbesartan (IRB) alone and in the presence of hydrochlorothiazide (HCT) is described. Measurements are made at the zero-crossing wavelength at 263.0 nm for IRB. The calibration graph was linear over the range 1.0-12.0 mg l(-1) of IRB, detection limit was 0.15 mg l(-1). HCT, in the presence of IRB was determined by direct spectrophotometric method at 317 nm. The calibration graph was linear over the range 2.0-50.0 mg l(-1) of HCT, detection limit was 0.25 mg l(-1). The proposed methods were successfully applied to the determinations of IRB and HCT in combined tablets.

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