Article

Healing a natural knockout of epithelial organogenesis.

Dept of Biosciences at Novum and Clinical Research Centre, Karolinska Institute, 14157 Huddinge, Sweden.
Trends in Molecular Medicine (impact factor: 10.35). 06/2002; 8(5):197-200. DOI:10.1016/S1471-4914(02)02342-0
Source: PubMed

ABSTRACT Ectodermal dysplasias are a large group of rare genetic disorders with developmental abnormalities in skin, teeth, hair and nails. Many of them are clinically serious and impair the life of patients. The cloning of the gene for the most common of them, X-linked anhidrotic ectodermal dysplasia, in 1996 opened the door to dissect novel developmental pathways at the molecular level. Since then, several new genes and proteins with novel functions have been identified.

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Keywords

dissect novel developmental pathways
 
Ectodermal dysplasias
 
molecular level
 
new genes
 
rare genetic disorders
 
X-linked anhidrotic ectodermal dysplasia
 

Juha Kere