Nail pigmentation caused by hydroxyurea: report of 9 cases.

Department of Dermatology, Ospedale S. Giovanni de Dio, University of Cagliari, Via Ospedale 54, 09124-Cagliari, Italy.
Journal of the American Academy of Dermatology (Impact Factor: 4.91). 08/2002; 47(1):146-7. DOI:10.1067/mjd.2002.120910
Source: PubMed

ABSTRACT We report a series of 9 patients, 6 men and 3 women, who presented nail hyperpigmentation arising between 6 and 24 months from the start of hydroxyurea therapy. The most commonly observed clinical pattern was that of longitudinal melanonychia. In only 1 patient, who was affected in all 20 nails, we observed longitudinal melanonychia, diffuse melanonychia, and hyperpigmentation of the skin.

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