Prevalence of narcolepsy symptomatology and diagnosis in the European general population. Neurology 58, 1826-33

Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, CA 94305, USA.
Neurology (Impact Factor: 8.3). 07/2002; 58(12):1826-33. DOI: 10.1212/WNL.58.12.1826
Source: PubMed

ABSTRACT To determine the prevalence of narcolepsy in the general population of five European countries (target population 205,890,882 inhabitants).
Overall, 18,980 randomly selected subjects were interviewed (participation rate 80.4%). These subjects were representative of the general population of the UK, Germany, Italy, Portugal, and Spain. They were interviewed by telephone using the Sleep-EVAL expert system, which provided narcolepsy diagnosis according to the International Classification of Sleep Disorders (ICSD).
Excessive daytime sleepiness was reported by 15% of the sample, with a higher prevalence in the UK and Germany. Napping two times or more in the same day was reported by 1.6% of the sample, with a significantly higher rate in Germany. Cataplexy (episodes of loss of muscle function related to a strong emotion), a cardinal symptom of narcolepsy, was found in 1.6% of the sample. An ICSD narcolepsy diagnosis was found in 0.047% of the sample: The narcolepsy was severe for 0.026% of the sample and moderate in 0.021%.
This is the first epidemiologic study that estimates the prevalence of narcolepsy in the general population of these five European countries. The disorder affects 47 individuals/100,000 inhabitants.

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    • "Son incidence suit une courbe d'incidence bimodale avec un pic à 15 ans et un second vers 35 ans [5]. Sa prévalence est estimée environ à 0,025 % [6]. Les mécanismes étiopathogéniques de la NSC et de l'HI restent mal connus, contrairement à ceux de la NC. "
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    Médecine du Sommeil 11/2014; 11(4). DOI:10.1016/j.msom.2014.09.001
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    • "Narcolepsy—genetically associated with HLA DQB1 ⁄ 06:02 (HLA) and the T-cell receptor (TCR)—is caused by the autoimmune destruction of neurons in the hypothalamus that produce the peptide hypocretin (orexin) (hormones that regulate the sleep cycle) [2] [3] [4] [5]. Narcolepsy is rare, occurring in less than one percent of the general population [6]. SP often occurs without narcolepsy (referred to as ''isolated'' sleep paralysis). "
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    • "Among these 26 patients with NC and IDs, 25 were sporadic and one familial. The prevalence of NC in Spain is considered to be similar to other European countries, as well as in North American populations, ranging between 0.025% and 0.40% (Ohayon et al., 2002), but there are no epidemiological studies in Spain confirming these figures. Eighteen patients (69.2%) had one ID associated, and eight (30.8%) had two IDs in addition to NC. "
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