Article

Peroxisome proliferator-activated receptor gamma (PPargamma) as a novel target for prostate cancer.

Massachusetts General Hospital, Boston 02114, USA.
Investigational New Drugs (impact factor: 3.36). 06/2002; 20(2):195-200. pp.195-200
Source: PubMed

ABSTRACT Peroxisome proliferator activated receptor-gamma (PPARgamma) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. PPARgamma is expressed at high levels in adipose tissue and plays a central role in adipocyte differentiation. Recent studies have implicated PPARgamma in the pathogenesis of several human malignancies. Here we review the evidence that PPARgamma contributes to prostate carcinogenesis and the potential for PPARgamma as a novel therapeutic target for prostate cancer.

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Keywords

adipocyte differentiation
 
adipose tissue
 
human malignancies
 
ligand-activated transcription factors
 
novel therapeutic target
 
nuclear receptor superfamily
 
Peroxisome proliferator activated receptor-gamma
 
prostate cancer
 
prostate carcinogenesis
 
Recent studies