A numerical study of blood flow in coronary artery bypass graft side-to-side anastomoses.

Department of Mechanical and Industrial Engineering, University of Toronto, Ontario, Canada.
Annals of Biomedical Engineering (Impact Factor: 3.23). 06/2002; 30(5):599-611. DOI: 10.1114/1.1481052
Source: PubMed

ABSTRACT When sequential grafts are used in multivessel coronary artery bypass grafting, the graft first supplies blood to one or more coronary arteries via a side-to-side anastomosis. We studied hemodynamics in idealized models of "parallel" and "diamond" side-to-side anastomoses, identifying features that might promote restenosis.
Blood flow was computed in three representative anastomosis configurations: parallel side-to-side, diamond side-to-side, and end-to-side. We compared configurations and the effect of host-graft diameter ratio.
Hemodynamic patterns depended strongly on anastomosis geometry and graft/host diameter ratio. In the distal graft, the diamond configuration had large areas of low wall shear stress (WSS) and high spatial WSS gradients. In the proximal graft the unfavorable WSS patterns were comparable for all models, while the distal portion of the host artery the diamond model was best. Models with smaller host arteries had smaller regions of low WSS.
The parallel configuration was preferred over the diamond for maintaining graft patency, while the diamond configuration appeared best for maintaining host artery patency. Since graft patency is critical, parallel configurations seem hemodynamically advantageous. Larger graft/host ratios have better hemodynamic performance than smaller ones.

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