Article

Donepezil in the treatment of hallucinations and delusions in Parkinson's disease.

Department of Neurological Sciences, La Sapienza University, Viale del'Università 30, I-00185 Rome, Italy.
Neurological Sciences (impact factor: 1.32). 05/2002; 23(1):41-3. DOI:10.1007/s100720200022 pp.41-3
Source: PubMed

ABSTRACT As cholinergic mechanisms may be at least partially responsible for hallucinations and delusions in Parkinson's disease (PD), we conducted an open study in 8 PD patients to assess the efficacy and tolerability of the cholinesterase inhibitor donepezil, 5 mg at bedtime for two months, in the treatment of these complications. Hallucinations and delusions improved significantly in all patients. Donezepil was overall well tolerated, but a deterioration in motor disability was noted in 2 out of 8 patients.

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Keywords

cholinergic mechanisms
 
cholinesterase inhibitor donepezil
 
complications
 
deterioration
 
efficacy
 
hallucinations
 
open study
 
Parkinson's disease