Management and Conduct of Randomized Controlled Trials

Maryland Medical Research Institute, 600 Wyndhurst Avenue, Baltimore, MD 21210, USA.
Epidemiologic Reviews (Impact Factor: 6.67). 02/2002; 24(1):12-25. DOI: 10.1093/epirev/24.1.12
Source: PubMed


In preparing to undertake a clinical trial, it may be helpful to keep in mind Fredrickson's description of clinical trials (31): "Field trials are indispensable. They will continue to be an ordeal. They lack glamour, they strain our resources and patience, and they protract the moment of truth to excruciating limits. Still, they are among the most challenging tests of our skills. I have no doubt that when the problem is well chosen, the study is appropriately designed, and that when all the populations concerned are made aware of the route and the goal, the reward can be commensurate with the effort. If, in major medical dilemmas, the alternative is to pay the costs of perpetual uncertainty, have we really any choice?"

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    ABSTRACT: The neural sources of human EEG electroencephalograph alpha activities have been investigated by an equivalent dipole fitting algorithm which takes the head shape into account. Two minutes of EEG were measured at 21 sites on the scalps of four young, healthy subjects. Single-moving-dipole fitting was performed, and a measure called proximity was introduced to evaluate the goodness of fit. The two-moving-dipole mode was found to model the human alpha field very well. The equivalent dipoles are located symmetrically in both hemispheres when the amplitude of the mean squared field is large, and they change orientation over time. The results confirm previous findings that there may be multiple sources of alpha waves
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