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HIV Vaccines: Biological and Clinical Considerations.

M Patricia D'Souza, Mary Allen, Margaret Johnston

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Journal Article: Current Infectious Disease Reports 09/2002; 4(4):359-368.

Abstract

The discovery of an HIV-1 vaccine is a high priority. Recent advances in HIV vaccine development include an improved understanding about virus biology and structure, and the development of quantitative techniques that enable a detailed analysis of vaccine-induced immune responses in humans. The preclinical vaccine pipeline looks healthy, and a common feature of the new vaccine strategies is their ability to attenuate clinical disease rather than prevent HIV infection in nonhuman primates. Human clinical trials to evaluate the safety and immunogenicity of these vaccine candidates and strategies are being actively pursued.

Source: PubMed

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Keywords

common feature
 
detailed analysis
 
HIV infection
 
HIV vaccine development
 
HIV-1 vaccine
 
improved understanding
 
new vaccine strategies
 
nonhuman primates
 
preclinical vaccine pipeline
 
quantitative techniques
 
Recent advances
 
vaccine-induced immune responses