Article

Helicobacter pylori may survive ampicillin treatment in the remnant stomach.

Department of Microbiology, Kitasato University School of Medicine, Kanagawa, Japan.
The Journal of Antibiotics (impact factor: 1.65). 06/2002; 55(5):495-8. pp.495-8
Source: PubMed

ABSTRACT Helicobacter pylori (H. pylori) is a Gram-negative curved rod-like or spiral bacterium that chronically infects the human gastric mucosa, and is a major risk factor for gastritis, gastric and duodenal ulcer and adenocarcinoma of the stomach. After partial gastrectomy, some patients may have persistent H. pylori infection for five years or more. In this study, we detected three bacteria, i.e., Klebsiella pneumoniae, Enterobacter aerogenes, and Escherichia coli, in the gastric juice of patients with a remnant stomach. Some of these bacteria produced beta-lactamase. These findings are potentially important since such bacteria could provide H. pylori with the chance to acquire drug resistance and to transfer drug resistance genes. This could be one reason why H. pylori is difficult to eradicate in the remnant stomach.

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Keywords

adenocarcinoma
 
drug resistance
 
duodenal ulcer
 
Enterobacter aerogenes
 
Gram-negative curved rod-like
 
H. pylori
 
Helicobacter pylori
 
human gastric mucosa
 
Klebsiella pneumoniae
 
major risk factor
 
patients
 
remnant stomach
 
spiral bacterium
 
transfer drug resistance genes