Article

Synthesis and SAR of azalide 3,6-ketal aromatic derivatives as potent Gram-positive and Gram-negative antibacterial agents.

Pfizer Global Research and Development, Groton Laboratories, Groton, CT 06340, USA.
Bioorganic & Medicinal Chemistry Letters (impact factor: 2.55). 10/2002; 12(17):2431-4.
Source: PubMed

ABSTRACT 3,6-Ketals of 15-membered azalide pseudoaglycones are a novel series of macrolide antibiotics. The aromatic derivatives of the azalide 3,6-ketals demonstrated potent antibacterial activities against both Gram-positive and Gram-negative bacteria.

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Keywords

15-membered azalide pseudoaglycones
 
aromatic derivatives
 
macrolide antibiotics
 
potent antibacterial activities
 

Hengmiao Cheng