Article

Effect of myelopeptide-2 on the development of spontaneous and urethane-induced tumors in mice.

M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
Bulletin of Experimental Biology and Medicine (impact factor: 0.27). 02/2002; 133(1):68-70. pp.68-70
Source: PubMed

ABSTRACT We studied the effect of endogenous immunoregulatory myelopeptide-2 on the development of spontaneous and urethane-induced lung adenomas. Long-term treatment with myelopeptide-2 (25 injections) in parallel with urethane poisoning decreased animal mortality caused by this carcinogen. Short-term treatment with myelopeptide-2 decreased the number of spontaneous and urethane-induced lung tumors in mice. Myelopeptide-2 delayed the appearance of urethane-induced tumors irrespective of the number of injections.

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Keywords

25 injections
 
animal mortality
 
endogenous immunoregulatory myelopeptide-2
 
mice
 
Short-term treatment
 
spontaneous
 
urethane-induced lung adenomas
 
urethane-induced lung tumors
 
urethane-induced tumors
 

A A Mikhailova