Apocrine differentiation in invasive pleomorphic lobular carcinoma with in situ ductal and lobular apocrine carcinoma: Case report

Department of Pathology, Marmara University Hospital, Istanbul, 81190, Turkey.
Pathology & Oncology Research (Impact Factor: 1.86). 02/2002; 8(2):151-2. DOI: 10.1007/BF03033728
Source: PubMed


Invasive pleomorphic lobular carcinoma (PLC) is a distinctive aggressive subtype of invasive lobular carcinomas (ILC). We report one case of PLC with in situ PLC and ductal carcinoma in situ with apocrine features.

Download full-text


Available from: Erkin Aribal,
  • Source

    01/2006; 50:548-552. DOI:10.1159/000326013
  • [Show abstract] [Hide abstract]
    ABSTRACT: Epithelial cells of fetal breast glandular structures, at the third trimester of pregnancy (28 weeks), produce GCDFP-15, in the absence of specific apocrine morphology. Apocrine epithelium of the breast may be a normal process of differentiation rather than a result of metaplasia, and it has been demonstrated that it is estrogen-receptor, progesterone-receptor and bcl-2 negative, but androgen-receptor (AR) positive. The significance of AR expression in apocrine epithelium is uncertain. Apocrine epithelium is seen in a wide spectrum of breast entities, ranging from benign lesions to invasive carcinoma. Breast cancer accounts 32% of all cancer cases among women and is the most common type of cancer in women. Little is known about breast carcinogenesis. Widely, it is accepted that breast cancer, like most other type of cancer, is being developed through the accumulation of genetic aberrations. Apocrine epithelium may reflect instability of the breast epithelium, creating an environment favouring further oncogenic alterations. In the last decade, several lines of evidence support the idea that some breast benign epithelial apocrine lesions are clonal lesions and may be considered as truly pre-malignant or precursors of breast carcinoma. Apocrine changes in many cases do not present any diagnostic difficulty; on the other hand, apocrine proliferations with cytologic atypia can be particularly difficult and challenging. The purpose of this study is to collect and highlight the areas of consensus in the literature as well as the controversial areas concerning the apocrine epithelium of the breast.
    Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 06/2006; 448(5):525-31. DOI:10.1007/s00428-005-0095-z · 2.65 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Il s’agit d’une patiente âgée de 27 ans, admise pour un nodule indolore du quadrant supéroexterne dusein droit découvert fortuitement. L’examen clinique du nodule n’objectivait ni de rétraction du mamelon, ni d’écoulement mamelonnaire, ni d’adénopathie axillaire. La patiente bénéficiait d’une tumorectomie suivie d’une mastectomie de type Patey. L’examen anatomopathologique concluait à un carcinome lobulaire à cellules pléomorphes. Le carcinome lobulaire du sein à cellules pléomorphes est une variétérare du cancer mammaire récemment individualisée, dotée d’un potentiel évolutif particulièrementagressif. Il s’organise sur le plan architectural comme un cancer lobulaire invasif, avec cependant, un pléomorphisme cytonucléaire trè s marqué posant des problèmes de diagnostic différentiel avec le carcinome canalaire infiltrant peu différencié. L’E-cadhérine est d’un apport considérable, elle permet en effet de trancher entre ces deux entités dont les modalités thérapeutiques et évolutives sont très différentes. We report a case of a 27-years-old woman with a lesion at the right breast, incidentally noted. The patient underwent tumour resection followed by a right mastectomy type “Patey”. Microscopic analysis of the tumour had recognised an invasive pleomorphic lobular carcinoma. Invasive pleomorphic lobular carcinoma (PLC) is a distinctive aggressive subtype of invasive lobular carcinomas (ILC). It has the typical infiltrating pattern of classical ILC of diffuse single cell spread but the nuclei aremore pleomorphic. Histological differential diagnosis with ductal carcinoma may be difficult, but it is important for this difference to be done. E-cadherine is a trans-membrane glycoprotein, typically expressed in ductal carcinoma, and loss of E-cadherine expression characterises invasive and in situ lobular carcinoma.
    Oncologie 11/2008; 10(11):668-672. DOI:10.1007/s10269-007-0788-9 · 0.06 Impact Factor
Show more