Childhood vaccinations and risk of asthma

Centers for Disease Control and Prevention, Atlanta, GA, USA.
The Pediatric Infectious Disease Journal (Impact Factor: 2.72). 07/2002; 21(6):498-504. DOI: 10.1097/00006454-200206000-00004
Source: PubMed


A few previous studies have suggested that childhood vaccines, particularly whole cell pertussis vaccine, may increase the risk of asthma. We evaluated the suggested association between childhood vaccinations and risk of asthma.
Cohort study involving 167,240 children who were enrolled in 4 large health maintenance organizations during 1991 to 1997, with follow-up from birth until at least 18 months to a maximum of 6 years of age. Vaccinations were ascertained through computerized immunization tracking systems, and onset of asthma was identified through computerized data on medical care encounters and medication dispensings.
In the study 18,407 children (11.0%) developed asthma, with a median age at onset of 11 months. The relative risks (95% confidence intervals) of asthma were: 0.92 (0.83 to 1.02) for diphtheria, tetanus and whole cell pertussis vaccine; 1.09 (0.9 to 1.23) for oral polio vaccine; 0.97 (0.91 to 1.04) for measles, mumps and rubella (MMR) vaccine; 1.18 (1.02 to 1.36) for Haemophilus influenzae type b (Hib); and 1.20 (1.13 to 1.27) for hepatitis B vaccine. The Hib result was not consistent across health maintenance organizations. In a subanalysis restricted to children who had at least 2 medical care encounters during their first year, the relative risks decreased to 1.07 (0.71 to 1.60) for Hib and 1.09 (0.88 to 1.34) for hepatitis B vaccine.
There is no association between diphtheria, tetanus and whole cell pertussis vaccine, oral polio vaccine or measles, mumps and rubella vaccine and the risk of asthma. The weak associations for Hib and hepatitis B vaccines seem to be at least partially accounted for by health care utilization or information bias.

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    • "The most consistent application of this method occurs within the health maintenance organisations in the United States of America and is known as the Vaccine Safety Datalink (VSD) project [5]. VSD has been used successfully to examine a number of safety signals generated by passive surveillance such as vaccination with the rhesus re-assortment rotaviral vaccine (Rotashield ® ) and infantile intussusception [6] [7] [8]. Vaccine data linkage has also been used intermittently in the United Kingdom, Scandinavia and Vietnam [9] [10] [11]. "
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    ABSTRACT: We linked the Australian Childhood Immunisation Register (ACIR) to South Australian (SA) hospital outcome data in order to evaluate the association between Measles Mumps and Rubella (MMR) and Diphtheria Tetanus Pertussis (DTP) vaccines and convulsions. Linkage occurred using probabilistic matching and data was analysed using the self-controlled case series methodology. An increase in febrile convulsions 6-11 days post-MMR vaccination was demonstrated which equates to a vaccine-attributable risk of 1 convulsion per 6753 vaccines. This study confirms the known association between MMR vaccination and febrile convulsions and in doing so demonstrates the feasibility of using the ACIR for data linkage and vaccine safety surveillance.
    Vaccine 06/2010; 28(26):4308-11. DOI:10.1016/j.vaccine.2010.04.021 · 3.62 Impact Factor
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    • "In a study of a birth cohort of a British general practice mentioned before [41], measles immunization was not found to be associated with an increased risk of atopic diseases. In addition, a large American cohort study mentioned before showed no increased risk of asthma after MMR vaccination [47]. A large American case-control study (mentioned before) showed no association of risk of wheeze during infancy with time having passed since MMR vaccination [48]. "
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    ABSTRACT: The prevalence of allergic diseases has increased considerably over the last decades. The hygiene hypothesis has emerged, linking reduced microbial exposure and infections early in life with the development of allergic diseases. Especially some of currently available non-replicating infant vaccines are unlikely to mimic a natural infection-mediated immune response that protects against the development of allergic diseases. Moreover, several studies suggested infant vaccinations to increase the risk of allergic diseases. To determine whether infant vaccinations increase the risk of developing allergic disease. We searched MEDLINE from 1966 to March 2003 and bibliography lists from retrieved articles, and consulted experts in the field to identify all articles relating vaccination to allergy. We selected epidemiological studies with original data on the correlation between vaccination with diphtheria, pertussis, tetanus (DPT), measles, mumps, rubella (MMR) and Bacillus Calmette-Guérin (BCG) vaccine in infancy and the development of allergic diseases, and assessed their quality and validity. Methodological design and quality varied considerably between the studies we reviewed. Many studies did not address possible confounders, such as the presence of lifestyle factors, leaving them prone to bias. The studies that offer the stronger evidence, including the only randomized controlled trial at issue published to date, indicate that the infant vaccinations we investigated do not increase the risk of developing allergic disease. Furthermore, BCG does not seem to reduce the risk of allergies. The reviewed epidemiological evidence indicates that, although possibly not contributing to optimal stimulation of the immune system in infancy, current infant vaccines do not cause allergic diseases.
    Vaccine 10/2004; 22(25-26):3375-85. DOI:10.1016/j.vaccine.2004.02.033 · 3.62 Impact Factor
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