Article

Mitochondrial processing peptidases.

Departments of Pediatric & Adolescent Medicine and Biochemistry & Molecular Biology, Mayo Clinic and Foundation, 200 First Street SW, Stabile 7-48, Rochester, MN 55905, USA.
Biochimica et Biophysica Acta (Impact Factor: 4.66). 10/2002; 1592(1):63-77. DOI: 10.1016/S0167-4889(02)00265-3
Source: PubMed

ABSTRACT Three peptidases are responsible for the proteolytic processing of both nuclearly and mitochondrially encoded precursor polypeptides targeted to the various subcompartments of the mitochondria. Mitochondrial processing peptidase (MPP) cleaves the vast majority of mitochondrial proteins, while inner membrane peptidase (IMP) and mitochondrial intermediate peptidase (MIP) process specific subsets of precursor polypeptides. All three enzymes are structurally and functionally conserved across species, and their human homologues begin to be recognized as potential players in mitochondrial disease.

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