Article

A meta-analysis of the association between DRD4 polymorphism and novelty seeking.

School of Business Administration, The Hebrew University of Jerusalem, Mt Scopus, Jerusalem, Israel.
Molecular Psychiatry (Impact Factor: 15.15). 02/2002; 7(7):712-7. DOI: 10.1038/sj.mp.4001082
Source: PubMed

ABSTRACT A meta-analytical review of 20 studies (n = 3907) of the association between DRD4 polymorphism and novelty seeking suggests the following conclusions: (a) on average, there is no association between DRD4 polymorphism and novelty seeking (average d = 0.06 with 95% CI of +/- 0.09), where 13 reports suggest that the presence of longer alleles is associated with higher novelty seeking scores and seven reports suggest the opposite; (b) there is a true heterogeneity among the studies (ie, unknown moderators do exist) but the strength of the association between DRD4 polymorphism and novelty seeking in the presence of any (unknown) moderator is likely to be weak; (c) search for moderators has not yielded any reliable explanation for the variability among studies. We propose that to find such moderators, theory-driven research for potential interaction, coupled with larger sample sizes should be employed. The growing availability of powerful statistical techniques, high-throughput genotyping and large numbers of polymorphic markers such as single nucleotide polymorphisms makes such proposed studies increasingly feasible.

0 Followers
 · 
121 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Human personality traits are moderately heritable but only recently have specific poly-morphisms been associated with particular personality dimensions especially anxiety-related and novelty-seeking traits. The first genome-wide scan for personality traits was recently carried out by Cloninger et al. [1998: Am J Med Genet 81:313–317] and his colleagues and they reported that a region on 8p21 showed linkage to TPQ Harm Avoidance, an anxiety-related personality trait. Towards replicating and extending these results, we examined both 8p21 and two additional chro-mosomal regions (1q21–24 and 22q12–13) for linkage to TPQ personality traits by genotyp-ing at least three microsatellite markers in each region in a group of 384 sibling pairs. We found evidence for linkage to TPQ HA at 8p21– 23 (Lod score ¼ 2.907) confirming in an independent sample the initial findings by Clonin-ger and his colleagues.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Dopaminergic system of the brain is believed to be strongly involved in normal and pathological behavioral phenotypes of attention. In metacontrast masking studies attentional effects on metacontrast are predominantly expressed when time intervals between a target stimulus and a masking stimulus are longer rather than shorter. Taken together, this predicts that variability in common genes known to be involved in dopaminergic function could interact with target/mask intervals in determining the effects of metacontrast masking. We tested this by genotyping participants of the masking experiment for the COMT Val158Met, DAT1 3'UTR 40bp VNTR, and DRD4 exon 3 48bp VNTR variability. We found that Val homozygotes and subjects with long repeat variants of the DRD4 gene showed relatively higher level of correct target perception with a longer target/mask time interval than with a shorter time interval while DAT1 variability did not have any effects. Implications of this result for the development of psychophysical testing based methods of screening for vulnerability/resilience in relation to the pathology of the dopaminergic systems related attentional dysfunction are considered. Copyright © 2015. Published by Elsevier Ltd.
    Neuropsychologia 03/2015; 71:112-118. DOI:10.1016/j.neuropsychologia.2015.03.022 · 3.45 Impact Factor
  • Source

Full-text

Download
265 Downloads
Available from
May 29, 2014