Molecular imprinted polymer coated QCM for the detection of nandrolone
ABSTRACT An acoustic wave sensor coated with an artificial biomimetic recognition element has been developed to selectively screen for nandrolone in the liquid phase. A highly specific covalently imprinted polymer (MIP) was spin coated onto one electrode of a quartz crystal microbalance (QCM) as a thin permeable film. Selective rebinding of the nandrolone was observed as a frequency shift in the QCM for concentrations up to 0.2 ppm with the sensor binding shown to favour nandrolone over analogous compounds.
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ABSTRACT: In this study, a novel quartz crystal microbalance (QCM) based on the modification of paraoxon-imprinted polymer onto a QCM with a high selectivity and sensitivity has been developed for the determination of paraoxon. The QCM sensor has characterized using AFM and ellipsometer. The performance of the QCM sensor has evaluated and presented good reproducibility, shorter response time (20 min), wider linear range (0.02–10 μM) and low detection limit (0.02 μM). The results have shown that the selectivity of QCM sensor has found as being very high in the presence of parathion which is similar in structure with paraoxon.Journal of Industrial and Engineering Chemistry 11/2013; 19(6):1788-1792. DOI:10.1016/j.jiec.2013.02.021 · 2.06 Impact Factor