An acoustic wave sensor coated with an artificial biomimetic recognition element has been developed to selectively screen for nandrolone in the liquid phase. A highly specific covalently imprinted polymer (MIP) was spin coated onto one electrode of a quartz crystal microbalance (QCM) as a thin permeable film. Selective rebinding of the nandrolone was observed as a frequency shift in the QCM for concentrations up to 0.2 ppm with the sensor binding shown to favour nandrolone over analogous compounds.
"MIPs were also widely employed as sensors for enantiomeric separation of different compounds such as R and S-propranolol, d and l-tryptophan, and d and l-serine enantiomers [147,155,156]. Several efforts to adapt MIP-based QCM sensing technology to chiral recognition of (S)-propranolol have been reported by Haupt and co-workers that created an enantioselective chiral recognition layers on the gold-coated surfaces of 5 MHz quartz crystals employing a poly(TRIM-co-MAA) MIP formulation . "
[Show abstract][Hide abstract] ABSTRACT: Molecular Imprinting Technology (MIT) is a technique to design artificial receptors with a predetermined selectivity and specificity for a given analyte, which can be used as ideal materials in various application fields. Molecularly Imprinted Polymers (MIPs), the polymeric matrices obtained using the imprinting technology, are robust molecular recognition elements able to mimic natural recognition entities, such as antibodies and biological receptors, useful to separate and analyze complicated samples such as biological fluids and environmental samples. The scope of this review is to provide a general overview on MIPs field discussing first general aspects in MIP preparation and then dealing with various application aspects. This review aims to outline the molecularly imprinted process and present a summary of principal application fields of molecularly imprinted polymers, focusing on chemical sensing, separation science, drug delivery and catalysis. Some significant aspects about preparation and application of the molecular imprinting polymers with examples taken from the recent literature will be discussed. Theoretical and experimental parameters for MIPs design in terms of the interaction between template and polymer functionalities will be considered and synthesis methods for the improvement of MIP recognition properties will also be presented.
International Journal of Molecular Sciences 12/2011; 12(9):5908-45. DOI:10.3390/ijms12095908 · 2.86 Impact Factor
"Molecular imprinting can lead to almost antibody-like selectivity (see e.g. for nandrolone imprints ). One example for this is shown in Figure 4: the left part – (A) shows the frequency responses of a 10-MHz-QCM coated with 8 kHz (i.e. "
[Show abstract][Hide abstract] ABSTRACT: Imprinting is a flexible and straightforward technique to generate selective sensormaterials e.g. for mass-sensitive detection. Inherently, the strategy suits both molecularanalytes and entire micro organisms or cells. Imprinted polyurethanes e.g. are capable ofdistinguishing the different xylene isomers with very appreciable selectivity factors.Combining imprinted titanates with surface transverse wave resonators (STW) leads to apowerful tool for detecting engine oil degradation, which is an excellent example foroxidative deterioration processes in a highly complex matrix. Surface imprints withgeometrically equal cavities exhibit clear chemical selectivity, as can e.g. be seen throughthe example of different human rhinovirus (HRV) serotypes. Another example is a bloodgroup-selective sensor prepared by templating with erythrocyte ghosts. Both the bloodgroupA and B imprinted material selectively distinguish between blood groups A, B and O,whereas no difference in sensor signal has been observed for AB, where both blood groupantigen types are present on the cell surface.
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