Molecular Imprinted Polymer Coated QCM for the Detection of Nandrolone

Department of Chemistry and Physics, The Nottingham Trent University, Clifton Lane, Nottingham, UK NG11 8NS.
The Analyst (Impact Factor: 3.91). 09/2002; 127(8):1024-6. DOI: 10.1039/B204949J
Source: PubMed

ABSTRACT An acoustic wave sensor coated with an artificial biomimetic recognition element has been developed to selectively screen for nandrolone in the liquid phase. A highly specific covalently imprinted polymer (MIP) was spin coated onto one electrode of a quartz crystal microbalance (QCM) as a thin permeable film. Selective rebinding of the nandrolone was observed as a frequency shift in the QCM for concentrations up to 0.2 ppm with the sensor binding shown to favour nandrolone over analogous compounds.

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