Molecular Imprinted Polymer Coated QCM for the Detection of Nandrolone

Department of Chemistry and Physics, The Nottingham Trent University, Clifton Lane, Nottingham, UK NG11 8NS.
The Analyst (Impact Factor: 4.11). 09/2002; 127(8):1024-6. DOI: 10.1039/B204949J
Source: PubMed


An acoustic wave sensor coated with an artificial biomimetic recognition element has been developed to selectively screen for nandrolone in the liquid phase. A highly specific covalently imprinted polymer (MIP) was spin coated onto one electrode of a quartz crystal microbalance (QCM) as a thin permeable film. Selective rebinding of the nandrolone was observed as a frequency shift in the QCM for concentrations up to 0.2 ppm with the sensor binding shown to favour nandrolone over analogous compounds.

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    • "MIPs were also widely employed as sensors for enantiomeric separation of different compounds such as R and S-propranolol, d and l-tryptophan, and d and l-serine enantiomers [147,155,156]. Several efforts to adapt MIP-based QCM sensing technology to chiral recognition of (S)-propranolol have been reported by Haupt and co-workers that created an enantioselective chiral recognition layers on the gold-coated surfaces of 5 MHz quartz crystals employing a poly(TRIM-co-MAA) MIP formulation [147]. "
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    • "Molecular imprinting can lead to almost antibody-like selectivity (see e.g. for nandrolone imprints [4]). One example for this is shown in Figure 4: the left part – (A) shows the frequency responses of a 10-MHz-QCM coated with 8 kHz (i.e. "
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