Isomeric acetoxy analogues of rofecoxib: A novel class of highly potent and selective cyclooxygenase-2 inhibitors

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
Bioorganic & Medicinal Chemistry Letters (Impact Factor: 2.33). 11/2002; 12(19):2753-6. DOI: 10.1016/S0960-894X(02)00537-1
Source: PubMed

ABSTRACT A group of isomers possessing a 2-, 3-, or 4-acetoxy moiety on the 3-phenyl substituent of rofecoxib were synthesized that exhibit highly potent, and selective, COX-2 inhibitory activity that have the potential to acetylate the COX-2 isozyme.


Available from: Edward E Knaus, Jan 20, 2014
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